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Anti-PTPRK/ R-PTP-kappa monoclonal antibody
Anti-PTPRK/ R-PTP-kappa antibody for FACS & in-vivo assay
Go to PTPRK/PTPRK products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1431-Ab-1/ GM-Tg-hg-MP1431-Ab-2 | Anti-Human PTPRK monoclonal antibody | Human |
| GM-Tg-rg-MP1431-Ab-1/ GM-Tg-rg-MP1431-Ab-2 | Anti-Rat PTPRK monoclonal antibody | Rat |
| GM-Tg-mg-MP1431-Ab-1/ GM-Tg-mg-MP1431-Ab-2 | Anti-Mouse PTPRK monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1431-Ab-1/ GM-Tg-cynog-MP1431-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PTPRK monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1431-Ab-1/ GM-Tg-felg-MP1431-Ab-2 | Anti-Feline PTPRK monoclonal antibody | Feline |
| GM-Tg-cang-MP1431-Ab-1/ GM-Tg-cang-MP1431-Ab-2 | Anti-Canine PTPRK monoclonal antibody | Canine |
| GM-Tg-bovg-MP1431-Ab-1/ GM-Tg-bovg-MP1431-Ab-2 | Anti-Bovine PTPRK monoclonal antibody | Bovine |
| GM-Tg-equg-MP1431-Ab-1/ GM-Tg-equg-MP1431-Ab-2 | Anti-Equine PTPRK monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1431-Ab-1/ GM-Tg-hg-MP1431-Ab-2; GM-Tg-rg-MP1431-Ab-1/ GM-Tg-rg-MP1431-Ab-2; GM-Tg-mg-MP1431-Ab-1/ GM-Tg-mg-MP1431-Ab-2; GM-Tg-cynog-MP1431-Ab-1/ GM-Tg-cynog-MP1431-Ab-2; GM-Tg-felg-MP1431-Ab-1/ GM-Tg-felg-MP1431-Ab-2; GM-Tg-cang-MP1431-Ab-1/ GM-Tg-cang-MP1431-Ab-2; GM-Tg-bovg-MP1431-Ab-1/ GM-Tg-bovg-MP1431-Ab-2; GM-Tg-equg-MP1431-Ab-1/ GM-Tg-equg-MP1431-Ab-2 |
| Products Name | Anti-PTPRK monoclonal antibody |
| Format | mab |
| Target Name | PTPRK |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PTPRK benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PTPRK/ R-PTP-kappa VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1431 |
| Target Name | PTPRK |
| Gene ID | 5796,19272,360302,711429,476290,101092366,509657,100073063 |
| Gene Symbol and Synonyms | PTPk,PTPRK,R-PTP-kappa,Rptpk,RPTPkappa |
| Uniprot Accession | Q15262 |
| Uniprot Entry Name | PTPRK_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000152894 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: PTPRK, gene name: PTPRK, also named as R-PTP-kappa. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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