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Anti-SAP/ PSAP/ GLBA monoclonal antibody
Anti-SAP/ PSAP/ GLBA antibody for FACS & in-vivo assay
Go to PSAP/PSAP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1417-Ab-1/ GM-Tg-hg-MP1417-Ab-2 | Anti-Human PSAP monoclonal antibody | Human |
| GM-Tg-rg-MP1417-Ab-1/ GM-Tg-rg-MP1417-Ab-2 | Anti-Rat PSAP monoclonal antibody | Rat |
| GM-Tg-mg-MP1417-Ab-1/ GM-Tg-mg-MP1417-Ab-2 | Anti-Mouse PSAP monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1417-Ab-1/ GM-Tg-cynog-MP1417-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PSAP monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1417-Ab-1/ GM-Tg-felg-MP1417-Ab-2 | Anti-Feline PSAP monoclonal antibody | Feline |
| GM-Tg-cang-MP1417-Ab-1/ GM-Tg-cang-MP1417-Ab-2 | Anti-Canine PSAP monoclonal antibody | Canine |
| GM-Tg-bovg-MP1417-Ab-1/ GM-Tg-bovg-MP1417-Ab-2 | Anti-Bovine PSAP monoclonal antibody | Bovine |
| GM-Tg-equg-MP1417-Ab-1/ GM-Tg-equg-MP1417-Ab-2 | Anti-Equine PSAP monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1417-Ab-1/ GM-Tg-hg-MP1417-Ab-2; GM-Tg-rg-MP1417-Ab-1/ GM-Tg-rg-MP1417-Ab-2; GM-Tg-mg-MP1417-Ab-1/ GM-Tg-mg-MP1417-Ab-2; GM-Tg-cynog-MP1417-Ab-1/ GM-Tg-cynog-MP1417-Ab-2; GM-Tg-felg-MP1417-Ab-1/ GM-Tg-felg-MP1417-Ab-2; GM-Tg-cang-MP1417-Ab-1/ GM-Tg-cang-MP1417-Ab-2; GM-Tg-bovg-MP1417-Ab-1/ GM-Tg-bovg-MP1417-Ab-2; GM-Tg-equg-MP1417-Ab-1/ GM-Tg-equg-MP1417-Ab-2 |
| Products Name | Anti-PSAP monoclonal antibody |
| Format | mab |
| Target Name | PSAP |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PSAP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species SAP/ PSAP/ GLBA VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP003316 | human PSAP Lentivirus particle |
| ORF Viral Vector | pGMLP003316 | human PSAP Lentivirus plasmid |
| ORF Viral Vector | pGMLPm003423 | mouse Psap Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003423 | mouse Psap Lentivirus particle |
Target information
| Target ID | GM-MP1417 |
| Target Name | PSAP |
| Gene ID | 5660,19156,25524,709510,479240,101080406,281433,100063520 |
| Gene Symbol and Synonyms | GLBA,PARK24,PSAP,PSAPD,SAP1,SAP2,SGP-1,SGP1A |
| Uniprot Accession | P07602,P10960,P26779 |
| Uniprot Entry Name | SAP_HUMAN,SAP_RAT,SAP_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Ovary Cancer, Malignant neoplasm of bladder |
| Gene Ensembl | ENSG00000197746 |
| Target Classification | N/A |
The target: PSAP, gene name: PSAP, also named as GLBA, SAP1. This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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