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Anti-PON2 monoclonal antibody
Anti-PON2 antibody for FACS & in-vivo assay
Go to PON2/PON2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1398-Ab-1/ GM-Tg-hg-MP1398-Ab-2 | Anti-Human PON2 monoclonal antibody | Human |
| GM-Tg-rg-MP1398-Ab-1/ GM-Tg-rg-MP1398-Ab-2 | Anti-Rat PON2 monoclonal antibody | Rat |
| GM-Tg-mg-MP1398-Ab-1/ GM-Tg-mg-MP1398-Ab-2 | Anti-Mouse PON2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1398-Ab-1/ GM-Tg-cynog-MP1398-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PON2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1398-Ab-1/ GM-Tg-felg-MP1398-Ab-2 | Anti-Feline PON2 monoclonal antibody | Feline |
| GM-Tg-cang-MP1398-Ab-1/ GM-Tg-cang-MP1398-Ab-2 | Anti-Canine PON2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1398-Ab-1/ GM-Tg-bovg-MP1398-Ab-2 | Anti-Bovine PON2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1398-Ab-1/ GM-Tg-equg-MP1398-Ab-2 | Anti-Equine PON2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1398-Ab-1/ GM-Tg-hg-MP1398-Ab-2; GM-Tg-rg-MP1398-Ab-1/ GM-Tg-rg-MP1398-Ab-2; GM-Tg-mg-MP1398-Ab-1/ GM-Tg-mg-MP1398-Ab-2; GM-Tg-cynog-MP1398-Ab-1/ GM-Tg-cynog-MP1398-Ab-2; GM-Tg-felg-MP1398-Ab-1/ GM-Tg-felg-MP1398-Ab-2; GM-Tg-cang-MP1398-Ab-1/ GM-Tg-cang-MP1398-Ab-2; GM-Tg-bovg-MP1398-Ab-1/ GM-Tg-bovg-MP1398-Ab-2; GM-Tg-equg-MP1398-Ab-1/ GM-Tg-equg-MP1398-Ab-2 |
| Products Name | Anti-PON2 monoclonal antibody |
| Format | mab |
| Target Name | PON2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PON2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PON2 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLV000453 | human PON2 Lentivirus particle |
| ORF Viral Vector | pGMLV000453 | human PON2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm005231 | mouse Pon2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005231 | mouse Pon2 Lentivirus particle |
Target information
| Target ID | GM-MP1398 |
| Target Name | PON2 |
| Gene ID | 5445,330260,296851,699107,403855,101094492,281417,100062686 |
| Gene Symbol and Synonyms | 6330405I24Rik,PON2 |
| Uniprot Accession | Q15165,Q6AXM8,P54832,Q58DS7 |
| Uniprot Entry Name | PON2_HUMAN,PON2_RAT,PON2_CANLF,PON2_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000105854 |
| Target Classification | N/A |
The target: PON2, gene name: PON2, also named as . This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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