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Anti-MYPR/ PLP1/ GPM6C monoclonal antibody
Anti-MYPR/ PLP1/ GPM6C antibody for FACS & in-vivo assay
Go to PLP1/PLP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1383-Ab-1/ GM-Tg-hg-MP1383-Ab-2 | Anti-Human PLP1 monoclonal antibody | Human |
| GM-Tg-rg-MP1383-Ab-1/ GM-Tg-rg-MP1383-Ab-2 | Anti-Rat PLP1 monoclonal antibody | Rat |
| GM-Tg-mg-MP1383-Ab-1/ GM-Tg-mg-MP1383-Ab-2 | Anti-Mouse PLP1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1383-Ab-1/ GM-Tg-cynog-MP1383-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PLP1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1383-Ab-1/ GM-Tg-felg-MP1383-Ab-2 | Anti-Feline PLP1 monoclonal antibody | Feline |
| GM-Tg-cang-MP1383-Ab-1/ GM-Tg-cang-MP1383-Ab-2 | Anti-Canine PLP1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1383-Ab-1/ GM-Tg-bovg-MP1383-Ab-2 | Anti-Bovine PLP1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1383-Ab-1/ GM-Tg-equg-MP1383-Ab-2 | Anti-Equine PLP1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1383-Ab-1/ GM-Tg-hg-MP1383-Ab-2; GM-Tg-rg-MP1383-Ab-1/ GM-Tg-rg-MP1383-Ab-2; GM-Tg-mg-MP1383-Ab-1/ GM-Tg-mg-MP1383-Ab-2; GM-Tg-cynog-MP1383-Ab-1/ GM-Tg-cynog-MP1383-Ab-2; GM-Tg-felg-MP1383-Ab-1/ GM-Tg-felg-MP1383-Ab-2; GM-Tg-cang-MP1383-Ab-1/ GM-Tg-cang-MP1383-Ab-2; GM-Tg-bovg-MP1383-Ab-1/ GM-Tg-bovg-MP1383-Ab-2; GM-Tg-equg-MP1383-Ab-1/ GM-Tg-equg-MP1383-Ab-2 |
| Products Name | Anti-PLP1 monoclonal antibody |
| Format | mab |
| Target Name | PLP1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PLP1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species MYPR/ PLP1/ GPM6C VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP003502 | human PLP1 Lentivirus particle |
| ORF Viral Vector | pGMLP003502 | human PLP1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002458 | mouse Plp1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002459 | mouse Plp1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002458 | mouse Plp1 Lentivirus particle |
| ORF Viral Vector | vGMLPm002459 | mouse Plp1 Lentivirus particle |
Target information
| Target ID | GM-MP1383 |
| Target Name | PLP1 |
| Gene ID | 5354,18823,24943,697887,481002,101098610,281410,100053823 |
| Gene Symbol and Synonyms | DM20,GPM6C,HLD1,jimpy,jp,MMPL,msd,PLP,PLP/DM20,PLP1,PMD,rsh,SPG2 |
| Uniprot Accession | P60201,P60203,P23294,P04116 |
| Uniprot Entry Name | MYPR_HUMAN,MYPR_RAT,MYPR_CANLF,MYPR_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Prostate Cancer |
| Gene Ensembl | ENSG00000123560 |
| Target Classification | N/A |
The target: PLP1, gene name: PLP1, also named as GPM6C, HLD1, MMPL, PLP, PLP/DM20, PMD, SPG2. This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant. [provided by RefSeq, Feb 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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