Anti-PCD19/ PCDH19/ EFMR monoclonal antibody

Anti-PCD19/ PCDH19/ EFMR antibody for FACS & in-vivo assay

Target products collectionGo to PCDH19/PCDH19 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1331-Ab-1/ GM-Tg-hg-MP1331-Ab-2Anti-Human PCDH19 monoclonal antibodyHuman
GM-Tg-rg-MP1331-Ab-1/ GM-Tg-rg-MP1331-Ab-2Anti-Rat PCDH19 monoclonal antibodyRat
GM-Tg-mg-MP1331-Ab-1/ GM-Tg-mg-MP1331-Ab-2Anti-Mouse PCDH19 monoclonal antibodyMouse
GM-Tg-cynog-MP1331-Ab-1/ GM-Tg-cynog-MP1331-Ab-2Anti-Cynomolgus/ Rhesus macaque PCDH19 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1331-Ab-1/ GM-Tg-felg-MP1331-Ab-2Anti-Feline PCDH19 monoclonal antibodyFeline
GM-Tg-cang-MP1331-Ab-1/ GM-Tg-cang-MP1331-Ab-2Anti-Canine PCDH19 monoclonal antibodyCanine
GM-Tg-bovg-MP1331-Ab-1/ GM-Tg-bovg-MP1331-Ab-2Anti-Bovine PCDH19 monoclonal antibodyBovine
GM-Tg-equg-MP1331-Ab-1/ GM-Tg-equg-MP1331-Ab-2Anti-Equine PCDH19 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1331-Ab-1/ GM-Tg-hg-MP1331-Ab-2; GM-Tg-rg-MP1331-Ab-1/ GM-Tg-rg-MP1331-Ab-2;
GM-Tg-mg-MP1331-Ab-1/ GM-Tg-mg-MP1331-Ab-2; GM-Tg-cynog-MP1331-Ab-1/ GM-Tg-cynog-MP1331-Ab-2;
GM-Tg-felg-MP1331-Ab-1/ GM-Tg-felg-MP1331-Ab-2; GM-Tg-cang-MP1331-Ab-1/ GM-Tg-cang-MP1331-Ab-2;
GM-Tg-bovg-MP1331-Ab-1/ GM-Tg-bovg-MP1331-Ab-2; GM-Tg-equg-MP1331-Ab-1/ GM-Tg-equg-MP1331-Ab-2
Products NameAnti-PCDH19 monoclonal antibody
Formatmab
Target NamePCDH19
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PCDH19 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species PCD19/ PCDH19/ EFMR VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1331
    Target NamePCDH19
    Gene ID57526,279653,317183,703042,119868465,101084175,524109,100059478
    Gene Symbol and SynonymsB530002L05Rik,DEE9,EFMR,EIEE9,Gm717,mKIAA1313,PCDH19,RGD1565392
    Uniprot AccessionQ8TAB3
    Uniprot Entry NamePCD19_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000165194
    Target ClassificationN/A

    The target: PCDH19, gene name: PCDH19, also named as EFMR, EIEE9. The protein encoded by this gene is a member of the delta-2 protocadherin subclass of the cadherin superfamily. The encoded protein is thought to be a calcium-dependent cell-adhesion protein that is primarily expressed in the brain. Mutations in this gene on human chromosome X are associated with sporadic infantile epileptic encephalopathy and to a female-restricted form of epilepsy (EFMR; also known as PCDH19RE). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.