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Anti-PARVB/ CGI-56 monoclonal antibody
Anti-PARVB/ CGI-56 antibody for FACS & in-vivo assay
Go to PARVB/PARVB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1323-Ab-1/ GM-Tg-hg-MP1323-Ab-2 | Anti-Human PARVB monoclonal antibody | Human |
| GM-Tg-rg-MP1323-Ab-1/ GM-Tg-rg-MP1323-Ab-2 | Anti-Rat PARVB monoclonal antibody | Rat |
| GM-Tg-mg-MP1323-Ab-1/ GM-Tg-mg-MP1323-Ab-2 | Anti-Mouse PARVB monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1323-Ab-1/ GM-Tg-cynog-MP1323-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PARVB monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1323-Ab-1/ GM-Tg-felg-MP1323-Ab-2 | Anti-Feline PARVB monoclonal antibody | Feline |
| GM-Tg-cang-MP1323-Ab-1/ GM-Tg-cang-MP1323-Ab-2 | Anti-Canine PARVB monoclonal antibody | Canine |
| GM-Tg-bovg-MP1323-Ab-1/ GM-Tg-bovg-MP1323-Ab-2 | Anti-Bovine PARVB monoclonal antibody | Bovine |
| GM-Tg-equg-MP1323-Ab-1/ GM-Tg-equg-MP1323-Ab-2 | Anti-Equine PARVB monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1323-Ab-1/ GM-Tg-hg-MP1323-Ab-2; GM-Tg-rg-MP1323-Ab-1/ GM-Tg-rg-MP1323-Ab-2; GM-Tg-mg-MP1323-Ab-1/ GM-Tg-mg-MP1323-Ab-2; GM-Tg-cynog-MP1323-Ab-1/ GM-Tg-cynog-MP1323-Ab-2; GM-Tg-felg-MP1323-Ab-1/ GM-Tg-felg-MP1323-Ab-2; GM-Tg-cang-MP1323-Ab-1/ GM-Tg-cang-MP1323-Ab-2; GM-Tg-bovg-MP1323-Ab-1/ GM-Tg-bovg-MP1323-Ab-2; GM-Tg-equg-MP1323-Ab-1/ GM-Tg-equg-MP1323-Ab-2 |
| Products Name | Anti-PARVB monoclonal antibody |
| Format | mab |
| Target Name | PARVB |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PARVB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PARVB/ CGI-56 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1323 |
| Target Name | PARVB |
| Gene ID | 29780,170736,362973,715859,481215,101087850,616294,100050839 |
| Gene Symbol and Synonyms | affixin,CGI-56,D15Gsk1,PARVB |
| Uniprot Accession | Q9HBI1 |
| Uniprot Entry Name | PARVB_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000188677 |
| Target Classification | N/A |
The target: PARVB, gene name: PARVB, also named as CGI-56. This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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