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Anti-AMD/ PAM/ PAL monoclonal antibody
Anti-AMD/ PAM/ PAL antibody for FACS & in-vivo assay
Go to PAM/PAM products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1311-Ab-1/ GM-Tg-hg-MP1311-Ab-2 | Anti-Human PAM monoclonal antibody | Human |
| GM-Tg-rg-MP1311-Ab-1/ GM-Tg-rg-MP1311-Ab-2 | Anti-Rat PAM monoclonal antibody | Rat |
| GM-Tg-mg-MP1311-Ab-1/ GM-Tg-mg-MP1311-Ab-2 | Anti-Mouse PAM monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1311-Ab-1/ GM-Tg-cynog-MP1311-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PAM monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1311-Ab-1/ GM-Tg-felg-MP1311-Ab-2 | Anti-Feline PAM monoclonal antibody | Feline |
| GM-Tg-cang-MP1311-Ab-1/ GM-Tg-cang-MP1311-Ab-2 | Anti-Canine PAM monoclonal antibody | Canine |
| GM-Tg-bovg-MP1311-Ab-1/ GM-Tg-bovg-MP1311-Ab-2 | Anti-Bovine PAM monoclonal antibody | Bovine |
| GM-Tg-equg-MP1311-Ab-1/ GM-Tg-equg-MP1311-Ab-2 | Anti-Equine PAM monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1311-Ab-1/ GM-Tg-hg-MP1311-Ab-2; GM-Tg-rg-MP1311-Ab-1/ GM-Tg-rg-MP1311-Ab-2; GM-Tg-mg-MP1311-Ab-1/ GM-Tg-mg-MP1311-Ab-2; GM-Tg-cynog-MP1311-Ab-1/ GM-Tg-cynog-MP1311-Ab-2; GM-Tg-felg-MP1311-Ab-1/ GM-Tg-felg-MP1311-Ab-2; GM-Tg-cang-MP1311-Ab-1/ GM-Tg-cang-MP1311-Ab-2; GM-Tg-bovg-MP1311-Ab-1/ GM-Tg-bovg-MP1311-Ab-2; GM-Tg-equg-MP1311-Ab-1/ GM-Tg-equg-MP1311-Ab-2 |
| Products Name | Anti-PAM monoclonal antibody |
| Format | mab |
| Target Name | PAM |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PAM benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species AMD/ PAM/ PAL VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1311 |
| Target Name | PAM |
| Gene ID | 5066,18484,25508,707733,479145,101084598,280890,791244 |
| Gene Symbol and Synonyms | PAL,PAM,PAM-1,PHM |
| Uniprot Accession | P19021,P14925,P10731 |
| Uniprot Entry Name | AMD_HUMAN,AMD_RAT,AMD_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000145730 |
| Target Classification | N/A |
The target: PAM, gene name: PAM, also named as PAL, PHM. This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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