Anti-NRN1L/ MRCC2446/ UNQ2446 monoclonal antibody

Anti-NRN1L/ MRCC2446/ UNQ2446 antibody for FACS & in-vivo assay

Target products collectionGo to NRN1L/NRN1L products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0905-Ab-1/ GM-Tg-hg-MP0905-Ab-2Anti-Human NRN1L monoclonal antibodyHuman
GM-Tg-rg-MP0905-Ab-1/ GM-Tg-rg-MP0905-Ab-2Anti-Rat NRN1L monoclonal antibodyRat
GM-Tg-mg-MP0905-Ab-1/ GM-Tg-mg-MP0905-Ab-2Anti-Mouse NRN1L monoclonal antibodyMouse
GM-Tg-cynog-MP0905-Ab-1/ GM-Tg-cynog-MP0905-Ab-2Anti-Cynomolgus/ Rhesus macaque NRN1L monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0905-Ab-1/ GM-Tg-felg-MP0905-Ab-2Anti-Feline NRN1L monoclonal antibodyFeline
GM-Tg-cang-MP0905-Ab-1/ GM-Tg-cang-MP0905-Ab-2Anti-Canine NRN1L monoclonal antibodyCanine
GM-Tg-bovg-MP0905-Ab-1/ GM-Tg-bovg-MP0905-Ab-2Anti-Bovine NRN1L monoclonal antibodyBovine
GM-Tg-equg-MP0905-Ab-1/ GM-Tg-equg-MP0905-Ab-2Anti-Equine NRN1L monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0905-Ab-1/ GM-Tg-hg-MP0905-Ab-2; GM-Tg-rg-MP0905-Ab-1/ GM-Tg-rg-MP0905-Ab-2;
GM-Tg-mg-MP0905-Ab-1/ GM-Tg-mg-MP0905-Ab-2; GM-Tg-cynog-MP0905-Ab-1/ GM-Tg-cynog-MP0905-Ab-2;
GM-Tg-felg-MP0905-Ab-1/ GM-Tg-felg-MP0905-Ab-2; GM-Tg-cang-MP0905-Ab-1/ GM-Tg-cang-MP0905-Ab-2;
GM-Tg-bovg-MP0905-Ab-1/ GM-Tg-bovg-MP0905-Ab-2; GM-Tg-equg-MP0905-Ab-1/ GM-Tg-equg-MP0905-Ab-2
Products NameAnti-NRN1L monoclonal antibody
Formatmab
Target NameNRN1L
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-NRN1L benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species NRN1L/ MRCC2446/ UNQ2446 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0905
    Target NameNRN1L
    Gene ID123904,234700,100189544,106995062,611107,101090821,100847846,100066355
    Gene Symbol and Synonymscpg15-2,G630049C14Rik,MRCC2446,NRN1L,UNQ2446
    Uniprot AccessionQ496H8
    Uniprot Entry NameNRN1L_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000188038
    Target ClassificationN/A

    The target: NRN1L, gene name: NRN1L, also named as MRCC2446, UNQ2446, cpg15-2. The protein encoded by this gene is extracellular and enhances both neurite growth and neuronal survival. The encoded protein is found both as a GPI anchored membrane-bound form and as a secreted form. This activity-related ligand functions as a homodimer or heterodimer. [provided by RefSeq, Feb 2017].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.