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Anti-NRG2/ DON1/ HRG2 monoclonal antibody
Anti-NRG2/ DON1/ HRG2 antibody for FACS & in-vivo assay
Go to NRG2/NRG2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0904-Ab-1/ GM-Tg-hg-MP0904-Ab-2 | Anti-Human NRG2 monoclonal antibody | Human |
| GM-Tg-rg-MP0904-Ab-1/ GM-Tg-rg-MP0904-Ab-2 | Anti-Rat NRG2 monoclonal antibody | Rat |
| GM-Tg-mg-MP0904-Ab-1/ GM-Tg-mg-MP0904-Ab-2 | Anti-Mouse NRG2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0904-Ab-1/ GM-Tg-cynog-MP0904-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NRG2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0904-Ab-1/ GM-Tg-felg-MP0904-Ab-2 | Anti-Feline NRG2 monoclonal antibody | Feline |
| GM-Tg-cang-MP0904-Ab-1/ GM-Tg-cang-MP0904-Ab-2 | Anti-Canine NRG2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0904-Ab-1/ GM-Tg-bovg-MP0904-Ab-2 | Anti-Bovine NRG2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0904-Ab-1/ GM-Tg-equg-MP0904-Ab-2 | Anti-Equine NRG2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0904-Ab-1/ GM-Tg-hg-MP0904-Ab-2; GM-Tg-rg-MP0904-Ab-1/ GM-Tg-rg-MP0904-Ab-2; GM-Tg-mg-MP0904-Ab-1/ GM-Tg-mg-MP0904-Ab-2; GM-Tg-cynog-MP0904-Ab-1/ GM-Tg-cynog-MP0904-Ab-2; GM-Tg-felg-MP0904-Ab-1/ GM-Tg-felg-MP0904-Ab-2; GM-Tg-cang-MP0904-Ab-1/ GM-Tg-cang-MP0904-Ab-2; GM-Tg-bovg-MP0904-Ab-1/ GM-Tg-bovg-MP0904-Ab-2; GM-Tg-equg-MP0904-Ab-1/ GM-Tg-equg-MP0904-Ab-2 |
| Products Name | Anti-NRG2 monoclonal antibody |
| Format | mab |
| Target Name | NRG2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NRG2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species NRG2/ DON1/ HRG2 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP0904-Ag-1 | neuregulin 2 (NRG2) protein |
Target information
| Target ID | GM-MP0904 |
| Target Name | NRG2 |
| Gene ID | 9542,100042150,432361,694995,487158,101090986,783452,100072444 |
| Gene Symbol and Synonyms | DON1,HRG2,NRG2,NTAK,NTAK alpha1,NTAK alpha2a,NTAK_alpha2a |
| Uniprot Accession | O14511,O35569 |
| Uniprot Entry Name | NRG2_HUMAN,NRG2_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000158458 |
| Target Classification | N/A |
The target: NRG2, gene name: NRG2, also named as DON1, HRG2, NTAK. This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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