Anti-NPHN/ NPHS1/ CNF monoclonal antibody

Anti-NPHN/ NPHS1/ CNF antibody for FACS & in-vivo assay

Target products collectionGo to NPHS1/NPHS1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0898-Ab-1/ GM-Tg-hg-MP0898-Ab-2Anti-Human NPHS1 monoclonal antibodyHuman
GM-Tg-rg-MP0898-Ab-1/ GM-Tg-rg-MP0898-Ab-2Anti-Rat NPHS1 monoclonal antibodyRat
GM-Tg-mg-MP0898-Ab-1/ GM-Tg-mg-MP0898-Ab-2Anti-Mouse NPHS1 monoclonal antibodyMouse
GM-Tg-cynog-MP0898-Ab-1/ GM-Tg-cynog-MP0898-Ab-2Anti-Cynomolgus/ Rhesus macaque NPHS1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0898-Ab-1/ GM-Tg-felg-MP0898-Ab-2Anti-Feline NPHS1 monoclonal antibodyFeline
GM-Tg-cang-MP0898-Ab-1/ GM-Tg-cang-MP0898-Ab-2Anti-Canine NPHS1 monoclonal antibodyCanine
GM-Tg-bovg-MP0898-Ab-1/ GM-Tg-bovg-MP0898-Ab-2Anti-Bovine NPHS1 monoclonal antibodyBovine
GM-Tg-equg-MP0898-Ab-1/ GM-Tg-equg-MP0898-Ab-2Anti-Equine NPHS1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0898-Ab-1/ GM-Tg-hg-MP0898-Ab-2; GM-Tg-rg-MP0898-Ab-1/ GM-Tg-rg-MP0898-Ab-2;
GM-Tg-mg-MP0898-Ab-1/ GM-Tg-mg-MP0898-Ab-2; GM-Tg-cynog-MP0898-Ab-1/ GM-Tg-cynog-MP0898-Ab-2;
GM-Tg-felg-MP0898-Ab-1/ GM-Tg-felg-MP0898-Ab-2; GM-Tg-cang-MP0898-Ab-1/ GM-Tg-cang-MP0898-Ab-2;
GM-Tg-bovg-MP0898-Ab-1/ GM-Tg-bovg-MP0898-Ab-2; GM-Tg-equg-MP0898-Ab-1/ GM-Tg-equg-MP0898-Ab-2
Products NameAnti-NPHS1 monoclonal antibody
Formatmab
Target NameNPHS1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-NPHS1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species NPHN/ NPHS1/ CNF VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0898
    Target NameNPHS1
    Gene ID4868,54631,64563,718929,484571,101101018,519706,100147013
    Gene Symbol and SynonymsCNF,nephrin,NephrinB,NPHN,NPHS1
    Uniprot AccessionO60500,Q9R044
    Uniprot Entry NameNPHN_HUMAN,NPHN_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000161270
    Target ClassificationN/A

    The target: NPHS1, gene name: NPHS1, also named as CNF, NPHN, nephrin. This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.[provided by RefSeq, Oct 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.