Anti-MCLN2/ MCOLN2/ TRP-ML2 monoclonal antibody

Anti-MCLN2/ MCOLN2/ TRP-ML2 antibody for FACS & in-vivo assay

Target products collectionGo to MCOLN2/MCOLN2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0801-Ab-1/ GM-Tg-hg-MP0801-Ab-2Anti-Human MCOLN2 monoclonal antibodyHuman
GM-Tg-rg-MP0801-Ab-1/ GM-Tg-rg-MP0801-Ab-2Anti-Rat MCOLN2 monoclonal antibodyRat
GM-Tg-mg-MP0801-Ab-1/ GM-Tg-mg-MP0801-Ab-2Anti-Mouse MCOLN2 monoclonal antibodyMouse
GM-Tg-cynog-MP0801-Ab-1/ GM-Tg-cynog-MP0801-Ab-2Anti-Cynomolgus/ Rhesus macaque MCOLN2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0801-Ab-1/ GM-Tg-felg-MP0801-Ab-2Anti-Feline MCOLN2 monoclonal antibodyFeline
GM-Tg-cang-MP0801-Ab-1/ GM-Tg-cang-MP0801-Ab-2Anti-Canine MCOLN2 monoclonal antibodyCanine
GM-Tg-bovg-MP0801-Ab-1/ GM-Tg-bovg-MP0801-Ab-2Anti-Bovine MCOLN2 monoclonal antibodyBovine
GM-Tg-equg-MP0801-Ab-1/ GM-Tg-equg-MP0801-Ab-2Anti-Equine MCOLN2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0801-Ab-1/ GM-Tg-hg-MP0801-Ab-2; GM-Tg-rg-MP0801-Ab-1/ GM-Tg-rg-MP0801-Ab-2;
GM-Tg-mg-MP0801-Ab-1/ GM-Tg-mg-MP0801-Ab-2; GM-Tg-cynog-MP0801-Ab-1/ GM-Tg-cynog-MP0801-Ab-2;
GM-Tg-felg-MP0801-Ab-1/ GM-Tg-felg-MP0801-Ab-2; GM-Tg-cang-MP0801-Ab-1/ GM-Tg-cang-MP0801-Ab-2;
GM-Tg-bovg-MP0801-Ab-1/ GM-Tg-bovg-MP0801-Ab-2; GM-Tg-equg-MP0801-Ab-1/ GM-Tg-equg-MP0801-Ab-2
Products NameAnti-MCOLN2 monoclonal antibody
Formatmab
Target NameMCOLN2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-MCOLN2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species MCLN2/ MCOLN2/ TRP-ML2 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0801
    Target NameMCOLN2
    Gene ID255231,68279,292168,710909,490186,101098395,532671,100052719
    Gene Symbol and Synonyms3300002C04Rik,MCOLN2,TRP-ML2,TRPML2
    Uniprot AccessionQ8IZK6
    Uniprot Entry NameMCLN2_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000153898
    Target ClassificationN/A

    The target: MCOLN2, gene name: MCOLN2, also named as TRP-ML2, TRPML2. Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 [PubMed 17662026]).[supplied by OMIM, Sep 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.