Anti-LRC4B/ LRRC4B/ HSM monoclonal antibody

Anti-LRC4B/ LRRC4B/ HSM antibody for FACS & in-vivo assay

Target products collectionGo to LRRC4B/LRRC4B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0763-Ab-1/ GM-Tg-hg-MP0763-Ab-2Anti-Human LRRC4B monoclonal antibodyHuman
GM-Tg-rg-MP0763-Ab-1/ GM-Tg-rg-MP0763-Ab-2Anti-Rat LRRC4B monoclonal antibodyRat
GM-Tg-mg-MP0763-Ab-1/ GM-Tg-mg-MP0763-Ab-2Anti-Mouse LRRC4B monoclonal antibodyMouse
GM-Tg-cynog-MP0763-Ab-1/ GM-Tg-cynog-MP0763-Ab-2Anti-Cynomolgus/ Rhesus macaque LRRC4B monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0763-Ab-1/ GM-Tg-felg-MP0763-Ab-2Anti-Feline LRRC4B monoclonal antibodyFeline
GM-Tg-cang-MP0763-Ab-1/ GM-Tg-cang-MP0763-Ab-2Anti-Canine LRRC4B monoclonal antibodyCanine
GM-Tg-bovg-MP0763-Ab-1/ GM-Tg-bovg-MP0763-Ab-2Anti-Bovine LRRC4B monoclonal antibodyBovine
GM-Tg-equg-MP0763-Ab-1/ GM-Tg-equg-MP0763-Ab-2Anti-Equine LRRC4B monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0763-Ab-1/ GM-Tg-hg-MP0763-Ab-2; GM-Tg-rg-MP0763-Ab-1/ GM-Tg-rg-MP0763-Ab-2;
GM-Tg-mg-MP0763-Ab-1/ GM-Tg-mg-MP0763-Ab-2; GM-Tg-cynog-MP0763-Ab-1/ GM-Tg-cynog-MP0763-Ab-2;
GM-Tg-felg-MP0763-Ab-1/ GM-Tg-felg-MP0763-Ab-2; GM-Tg-cang-MP0763-Ab-1/ GM-Tg-cang-MP0763-Ab-2;
GM-Tg-bovg-MP0763-Ab-1/ GM-Tg-bovg-MP0763-Ab-2; GM-Tg-equg-MP0763-Ab-1/ GM-Tg-equg-MP0763-Ab-2
Products NameAnti-LRRC4B monoclonal antibody
Formatmab
Target NameLRRC4B
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-LRRC4B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species LRC4B/ LRRC4B/ HSM VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0763
    Target NameLRRC4B
    Gene ID94030,272381,308571,719338,484361,101098910,539607,100146202
    Gene Symbol and SynonymsA830007M12,HSM,LRIG4,LRRC4B,NGL-3,Ngl3
    Uniprot AccessionQ9NT99,P0CC10
    Uniprot Entry NameLRC4B_HUMAN,LRC4B_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000131409
    Target ClassificationN/A

    The target: LRRC4B, gene name: LRRC4B, also named as HSM, LRIG4, NGL-3. Predicted to enable signaling receptor binding activity. Predicted to be involved in regulation of synapse assembly and synaptic membrane adhesion. Predicted to be located in cerebellar mossy fiber and presynaptic membrane. Predicted to be active in glutamatergic synapse and plasma membrane. Predicted to be integral component of postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.