Anti-KLRB1/ CD161/ CLEC5B monoclonal antibody

Anti-KLRB1/ CD161/ CLEC5B antibody for FACS & in-vivo assay

Target products collectionGo to KLRB1/KLRB1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0710-Ab-1/ GM-Tg-hg-MP0710-Ab-2Anti-Human KLRB1 monoclonal antibodyHuman
GM-Tg-rg-MP0710-Ab-1/ GM-Tg-rg-MP0710-Ab-2Anti-Rat KLRB1 monoclonal antibodyRat
GM-Tg-mg-MP0710-Ab-1/ GM-Tg-mg-MP0710-Ab-2Anti-Mouse KLRB1 monoclonal antibodyMouse
GM-Tg-cynog-MP0710-Ab-1/ GM-Tg-cynog-MP0710-Ab-2Anti-Cynomolgus/ Rhesus macaque KLRB1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0710-Ab-1/ GM-Tg-felg-MP0710-Ab-2Anti-Feline KLRB1 monoclonal antibodyFeline
GM-Tg-cang-MP0710-Ab-1/ GM-Tg-cang-MP0710-Ab-2Anti-Canine KLRB1 monoclonal antibodyCanine
GM-Tg-bovg-MP0710-Ab-1/ GM-Tg-bovg-MP0710-Ab-2Anti-Bovine KLRB1 monoclonal antibodyBovine
GM-Tg-equg-MP0710-Ab-1/ GM-Tg-equg-MP0710-Ab-2Anti-Equine KLRB1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0710-Ab-1/ GM-Tg-hg-MP0710-Ab-2; GM-Tg-rg-MP0710-Ab-1/ GM-Tg-rg-MP0710-Ab-2;
GM-Tg-mg-MP0710-Ab-1/ GM-Tg-mg-MP0710-Ab-2; GM-Tg-cynog-MP0710-Ab-1/ GM-Tg-cynog-MP0710-Ab-2;
GM-Tg-felg-MP0710-Ab-1/ GM-Tg-felg-MP0710-Ab-2; GM-Tg-cang-MP0710-Ab-1/ GM-Tg-cang-MP0710-Ab-2;
GM-Tg-bovg-MP0710-Ab-1/ GM-Tg-bovg-MP0710-Ab-2; GM-Tg-equg-MP0710-Ab-1/ GM-Tg-equg-MP0710-Ab-2
Products NameAnti-KLRB1 monoclonal antibody
Formatmab
Target NameKLRB1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-KLRB1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species KLRB1/ CD161/ CLEC5B VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0710
    Target NameKLRB1
    Gene ID3820,100043861,689817,100430783,100684789,101081737,100053558
    Gene Symbol and Synonyms4930431A04Rik,CD161,CLEC5B,Gm4696,hNKR-P1A,KLRB1,Klrb1d,Klrb1f,Klrb1g,Klrb6,Ly-55,Ly55,NKR,NKR-P1,NKR-P1A,Nkr-p1e,NKR-P1G,Nkrp-1e,NKRP1A,Nkrp1g
    Uniprot AccessionQ12918,Q0ZUP0
    Uniprot Entry NameKLRB1_HUMAN,KLRB1_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000111796
    Target ClassificationN/A

    The target: KLRB1, gene name: KLRB1, also named as CD161, CLEC5B, NKR, NKR-P1, NKR-P1A, NKRP1A, hNKR-P1A. Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.