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Anti-KLOT/ KL/ HFTC3 monoclonal antibody
Anti-KLOT/ KL/ HFTC3 antibody for FACS & in-vivo assay
Go to KL/KL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0709-Ab-1/ GM-Tg-hg-MP0709-Ab-2 | Anti-Human KL monoclonal antibody | Human |
| GM-Tg-rg-MP0709-Ab-1/ GM-Tg-rg-MP0709-Ab-2 | Anti-Rat KL monoclonal antibody | Rat |
| GM-Tg-mg-MP0709-Ab-1/ GM-Tg-mg-MP0709-Ab-2 | Anti-Mouse KL monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0709-Ab-1/ GM-Tg-cynog-MP0709-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KL monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0709-Ab-1/ GM-Tg-felg-MP0709-Ab-2 | Anti-Feline KL monoclonal antibody | Feline |
| GM-Tg-cang-MP0709-Ab-1/ GM-Tg-cang-MP0709-Ab-2 | Anti-Canine KL monoclonal antibody | Canine |
| GM-Tg-bovg-MP0709-Ab-1/ GM-Tg-bovg-MP0709-Ab-2 | Anti-Bovine KL monoclonal antibody | Bovine |
| GM-Tg-equg-MP0709-Ab-1/ GM-Tg-equg-MP0709-Ab-2 | Anti-Equine KL monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0709-Ab-1/ GM-Tg-hg-MP0709-Ab-2; GM-Tg-rg-MP0709-Ab-1/ GM-Tg-rg-MP0709-Ab-2; GM-Tg-mg-MP0709-Ab-1/ GM-Tg-mg-MP0709-Ab-2; GM-Tg-cynog-MP0709-Ab-1/ GM-Tg-cynog-MP0709-Ab-2; GM-Tg-felg-MP0709-Ab-1/ GM-Tg-felg-MP0709-Ab-2; GM-Tg-cang-MP0709-Ab-1/ GM-Tg-cang-MP0709-Ab-2; GM-Tg-bovg-MP0709-Ab-1/ GM-Tg-bovg-MP0709-Ab-2; GM-Tg-equg-MP0709-Ab-1/ GM-Tg-equg-MP0709-Ab-2 |
| Products Name | Anti-KL monoclonal antibody |
| Format | mab |
| Target Name | KL |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-KL benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species KLOT/ KL/ HFTC3 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP0709-Ag-1 | klotho (KL) protein |
| ORF Viral Vector | pGMAD000264 | mouse Kl Adenovirus plasmid |
| ORF Viral Vector | pGMAAV000258 | house mouse Kl AAV plasmid |
| ORF Viral Vector | vGMAD000264 | mouse Kl Adenovirus particle |
| ORF Viral Vector | vGMAAV000258 | house mouse Kl AAV particle |
Target information
| Target ID | GM-MP0709 |
| Target Name | KL |
| Gene ID | 9365,16591,83504,714042,100685604,101082617,784635,100064836 |
| Gene Symbol and Synonyms | alpha-kl,HFTC3,KL,KLA |
| Uniprot Accession | Q9UEF7,Q9Z2Y9 |
| Uniprot Entry Name | KLOT_HUMAN,KLOT_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000133116 |
| Target Classification | N/A |
The target: KL, gene name: KL, also named as HFTC3. This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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