Anti-IRPL1/ IL1RAPL1/ IL-1-RAPL-1 monoclonal antibody

Anti-IRPL1/ IL1RAPL1/ IL-1-RAPL-1 antibody for FACS & in-vivo assay

Target products collectionGo to IL1RAPL1/IL1RAPL1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0620-Ab-1/ GM-Tg-hg-MP0620-Ab-2Anti-Human IL1RAPL1 monoclonal antibodyHuman
GM-Tg-rg-MP0620-Ab-1/ GM-Tg-rg-MP0620-Ab-2Anti-Rat IL1RAPL1 monoclonal antibodyRat
GM-Tg-mg-MP0620-Ab-1/ GM-Tg-mg-MP0620-Ab-2Anti-Mouse IL1RAPL1 monoclonal antibodyMouse
GM-Tg-cynog-MP0620-Ab-1/ GM-Tg-cynog-MP0620-Ab-2Anti-Cynomolgus/ Rhesus macaque IL1RAPL1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0620-Ab-1/ GM-Tg-felg-MP0620-Ab-2Anti-Feline IL1RAPL1 monoclonal antibodyFeline
GM-Tg-cang-MP0620-Ab-1/ GM-Tg-cang-MP0620-Ab-2Anti-Canine IL1RAPL1 monoclonal antibodyCanine
GM-Tg-bovg-MP0620-Ab-1/ GM-Tg-bovg-MP0620-Ab-2Anti-Bovine IL1RAPL1 monoclonal antibodyBovine
GM-Tg-equg-MP0620-Ab-1/ GM-Tg-equg-MP0620-Ab-2Anti-Equine IL1RAPL1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0620-Ab-1/ GM-Tg-hg-MP0620-Ab-2; GM-Tg-rg-MP0620-Ab-1/ GM-Tg-rg-MP0620-Ab-2;
GM-Tg-mg-MP0620-Ab-1/ GM-Tg-mg-MP0620-Ab-2; GM-Tg-cynog-MP0620-Ab-1/ GM-Tg-cynog-MP0620-Ab-2;
GM-Tg-felg-MP0620-Ab-1/ GM-Tg-felg-MP0620-Ab-2; GM-Tg-cang-MP0620-Ab-1/ GM-Tg-cang-MP0620-Ab-2;
GM-Tg-bovg-MP0620-Ab-1/ GM-Tg-bovg-MP0620-Ab-2; GM-Tg-equg-MP0620-Ab-1/ GM-Tg-equg-MP0620-Ab-2
Products NameAnti-IL1RAPL1 monoclonal antibody
Formatmab
Target NameIL1RAPL1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IL1RAPL1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species IRPL1/ IL1RAPL1/ IL-1-RAPL-1 VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-MP0620-Ag-1interleukin 1 receptor accessory protein-like 1 (IL1RAPL1) protein


    Target information

    Target IDGM-MP0620
    Target NameIL1RAPL1
    Gene ID11141,331461,317553,706588,491800,101082883,541298,100052404
    Gene Symbol and Synonyms6330532G10Rik,C030039N24,IL-1-RAPL-1,IL-1RAPL-1,IL1R8,IL1RAPL,IL1RAPL-1,IL1RAPL1,MRX10,MRX21,MRX34,OPHN4,TIGIRR-2
    Uniprot AccessionQ9NZN1,P59824
    Uniprot Entry NameIRPL1_HUMAN,IRPL1_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryCytokine Target
    DiseaseN/A
    Gene EnsemblENSG00000169306
    Target ClassificationN/A

    The target: IL1RAPL1, gene name: IL1RAPL1, also named as IL-1-RAPL-1, IL-1RAPL-1, IL1R8, IL1RAPL, IL1RAPL-1, MRX10, MRX21, MRX34, OPHN4, TIGIRR-2. The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. This protein has an N-terminal signal peptide, three extracellular immunoglobulin Ig-like domains, a transmembrane domain, an intracellular Toll/IL-1R domain, and a long C-terminal tail which interacts with multiple signalling molecules. This gene is located at a region on chromosome X that is associated with a non-syndromic form of X-linked intellectual disability. Deletions and mutations in this gene were found in patients with intellectual disability. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities, and plays a role in synapse formation and stabilization. [provided by RefSeq, Jul 2017].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.