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Anti-IL18R/ IL18R1/ CD218a monoclonal antibody
Anti-IL18R/ IL18R1/ CD218a antibody for FACS & in-vivo assay
Go to IL18R1/IL18R1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0619-Ab-1/ GM-Tg-hg-MP0619-Ab-2 | Anti-Human IL18R1 monoclonal antibody | Human |
| GM-Tg-rg-MP0619-Ab-1/ GM-Tg-rg-MP0619-Ab-2 | Anti-Rat IL18R1 monoclonal antibody | Rat |
| GM-Tg-mg-MP0619-Ab-1/ GM-Tg-mg-MP0619-Ab-2 | Anti-Mouse IL18R1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0619-Ab-1/ GM-Tg-cynog-MP0619-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL18R1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0619-Ab-1/ GM-Tg-felg-MP0619-Ab-2 | Anti-Feline IL18R1 monoclonal antibody | Feline |
| GM-Tg-cang-MP0619-Ab-1/ GM-Tg-cang-MP0619-Ab-2 | Anti-Canine IL18R1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0619-Ab-1/ GM-Tg-bovg-MP0619-Ab-2 | Anti-Bovine IL18R1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0619-Ab-1/ GM-Tg-equg-MP0619-Ab-2 | Anti-Equine IL18R1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0619-Ab-1/ GM-Tg-hg-MP0619-Ab-2; GM-Tg-rg-MP0619-Ab-1/ GM-Tg-rg-MP0619-Ab-2; GM-Tg-mg-MP0619-Ab-1/ GM-Tg-mg-MP0619-Ab-2; GM-Tg-cynog-MP0619-Ab-1/ GM-Tg-cynog-MP0619-Ab-2; GM-Tg-felg-MP0619-Ab-1/ GM-Tg-felg-MP0619-Ab-2; GM-Tg-cang-MP0619-Ab-1/ GM-Tg-cang-MP0619-Ab-2; GM-Tg-bovg-MP0619-Ab-1/ GM-Tg-bovg-MP0619-Ab-2; GM-Tg-equg-MP0619-Ab-1/ GM-Tg-equg-MP0619-Ab-2 |
| Products Name | Anti-IL18R1 monoclonal antibody |
| Format | mab |
| Target Name | IL18R1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL18R1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species IL18R/ IL18R1/ CD218a VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP0619-Ag-1 | interleukin 18 receptor 1 (IL18R1) protein |
| ORF Viral Vector | pGMLPm002056 | mouse Il18r1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002056 | mouse Il18r1 Lentivirus particle |
Target information
| Target ID | GM-MP0619 |
| Target Name | IL18R1 |
| Gene ID | 8809,16182,301365,100426588,611438,493938,407221,100058269 |
| Gene Symbol and Synonyms | CD218a,CDw218a,IL-18R-alpha,IL-18Ra,IL-18Ralpha,IL-1Rrp,IL18R1,IL18RA,Il18ralpha,IL18Ralpha2,IL1RRP |
| Uniprot Accession | Q13478 |
| Uniprot Entry Name | IL18R_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000115604 |
| Target Classification | N/A |
The target: IL18R1, gene name: IL18R1, also named as CD218a, CDw218a, IL-1Rrp, IL18RA, IL1RRP. The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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