- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-HLAF/ HLA-F/ CDA12 monoclonal antibody
Anti-HLAF/ HLA-F/ CDA12 antibody for FACS & in-vivo assay
Go to HLA-F/HLA-F products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0589-Ab-1/ GM-Tg-hg-MP0589-Ab-2 | Anti-Human HLA-F monoclonal antibody | Human |
| GM-Tg-rg-MP0589-Ab-1/ GM-Tg-rg-MP0589-Ab-2 | Anti-Rat HLA-F monoclonal antibody | Rat |
| GM-Tg-mg-MP0589-Ab-1/ GM-Tg-mg-MP0589-Ab-2 | Anti-Mouse HLA-F monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0589-Ab-1/ GM-Tg-cynog-MP0589-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HLA-F monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0589-Ab-1/ GM-Tg-felg-MP0589-Ab-2 | Anti-Feline HLA-F monoclonal antibody | Feline |
| GM-Tg-cang-MP0589-Ab-1/ GM-Tg-cang-MP0589-Ab-2 | Anti-Canine HLA-F monoclonal antibody | Canine |
| GM-Tg-bovg-MP0589-Ab-1/ GM-Tg-bovg-MP0589-Ab-2 | Anti-Bovine HLA-F monoclonal antibody | Bovine |
| GM-Tg-equg-MP0589-Ab-1/ GM-Tg-equg-MP0589-Ab-2 | Anti-Equine HLA-F monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0589-Ab-1/ GM-Tg-hg-MP0589-Ab-2; GM-Tg-rg-MP0589-Ab-1/ GM-Tg-rg-MP0589-Ab-2; GM-Tg-mg-MP0589-Ab-1/ GM-Tg-mg-MP0589-Ab-2; GM-Tg-cynog-MP0589-Ab-1/ GM-Tg-cynog-MP0589-Ab-2; GM-Tg-felg-MP0589-Ab-1/ GM-Tg-felg-MP0589-Ab-2; GM-Tg-cang-MP0589-Ab-1/ GM-Tg-cang-MP0589-Ab-2; GM-Tg-bovg-MP0589-Ab-1/ GM-Tg-bovg-MP0589-Ab-2; GM-Tg-equg-MP0589-Ab-1/ GM-Tg-equg-MP0589-Ab-2 |
| Products Name | Anti-HLA-F monoclonal antibody |
| Format | mab |
| Target Name | HLA-F |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HLA-F benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species HLAF/ HLA-F/ CDA12 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0589 |
| Target Name | HLA-F |
| Gene ID | 3134 |
| Gene Symbol and Synonyms | CDA12,HLA-5.4,HLA-CDA12,HLA-F,HLAF |
| Uniprot Accession | P30511 |
| Uniprot Entry Name | HLAF_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000204642 |
| Target Classification | N/A |
The target: HLA-F, gene name: HLA-F, also named as CDA12, HLA-5.4, HLA-CDA12, HLAF. This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
