Anti-DQA2/ HLA-DQA2/ DC-alpha monoclonal antibody

Anti-DQA2/ HLA-DQA2/ DC-alpha antibody for FACS & in-vivo assay

Target products collectionGo to HLA-DQA2/HLA-DQA2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0585-Ab-1/ GM-Tg-hg-MP0585-Ab-2Anti-Human HLA-DQA2 monoclonal antibodyHuman
GM-Tg-rg-MP0585-Ab-1/ GM-Tg-rg-MP0585-Ab-2Anti-Rat HLA-DQA2 monoclonal antibodyRat
GM-Tg-mg-MP0585-Ab-1/ GM-Tg-mg-MP0585-Ab-2Anti-Mouse HLA-DQA2 monoclonal antibodyMouse
GM-Tg-cynog-MP0585-Ab-1/ GM-Tg-cynog-MP0585-Ab-2Anti-Cynomolgus/ Rhesus macaque HLA-DQA2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0585-Ab-1/ GM-Tg-felg-MP0585-Ab-2Anti-Feline HLA-DQA2 monoclonal antibodyFeline
GM-Tg-cang-MP0585-Ab-1/ GM-Tg-cang-MP0585-Ab-2Anti-Canine HLA-DQA2 monoclonal antibodyCanine
GM-Tg-bovg-MP0585-Ab-1/ GM-Tg-bovg-MP0585-Ab-2Anti-Bovine HLA-DQA2 monoclonal antibodyBovine
GM-Tg-equg-MP0585-Ab-1/ GM-Tg-equg-MP0585-Ab-2Anti-Equine HLA-DQA2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0585-Ab-1/ GM-Tg-hg-MP0585-Ab-2; GM-Tg-rg-MP0585-Ab-1/ GM-Tg-rg-MP0585-Ab-2;
GM-Tg-mg-MP0585-Ab-1/ GM-Tg-mg-MP0585-Ab-2; GM-Tg-cynog-MP0585-Ab-1/ GM-Tg-cynog-MP0585-Ab-2;
GM-Tg-felg-MP0585-Ab-1/ GM-Tg-felg-MP0585-Ab-2; GM-Tg-cang-MP0585-Ab-1/ GM-Tg-cang-MP0585-Ab-2;
GM-Tg-bovg-MP0585-Ab-1/ GM-Tg-bovg-MP0585-Ab-2; GM-Tg-equg-MP0585-Ab-1/ GM-Tg-equg-MP0585-Ab-2
Products NameAnti-HLA-DQA2 monoclonal antibody
Formatmab
Target NameHLA-DQA2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-HLA-DQA2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species DQA2/ HLA-DQA2/ DC-alpha VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0585
    Target NameHLA-DQA2
    Gene ID3118
    Gene Symbol and SynonymsDC-alpha,DQA1,DX-ALPHA,HLA-DCA,HLA-DQA2,HLA-DXA,HLADQA2
    Uniprot AccessionP01906
    Uniprot Entry NameDQA2_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000237541
    Target ClassificationN/A

    The target: HLA-DQA2, gene name: HLA-DQA2, also named as DC-alpha, DX-ALPHA, HLA-DCA, HLA-DXA, HLADQA2. This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells. [provided by RefSeq, Jun 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.