Anti-GPC1/ glypican monoclonal antibody

Anti-GPC1/ glypican antibody for FACS & in-vivo assay

Target products collectionGo to GPC1/GPC1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0490-Ab-1/ GM-Tg-hg-MP0490-Ab-2Anti-Human GPC1 monoclonal antibodyHuman
GM-Tg-rg-MP0490-Ab-1/ GM-Tg-rg-MP0490-Ab-2Anti-Rat GPC1 monoclonal antibodyRat
GM-Tg-mg-MP0490-Ab-1/ GM-Tg-mg-MP0490-Ab-2Anti-Mouse GPC1 monoclonal antibodyMouse
GM-Tg-cynog-MP0490-Ab-1/ GM-Tg-cynog-MP0490-Ab-2Anti-Cynomolgus/ Rhesus macaque GPC1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0490-Ab-1/ GM-Tg-felg-MP0490-Ab-2Anti-Feline GPC1 monoclonal antibodyFeline
GM-Tg-cang-MP0490-Ab-1/ GM-Tg-cang-MP0490-Ab-2Anti-Canine GPC1 monoclonal antibodyCanine
GM-Tg-bovg-MP0490-Ab-1/ GM-Tg-bovg-MP0490-Ab-2Anti-Bovine GPC1 monoclonal antibodyBovine
GM-Tg-equg-MP0490-Ab-1/ GM-Tg-equg-MP0490-Ab-2Anti-Equine GPC1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0490-Ab-1/ GM-Tg-hg-MP0490-Ab-2; GM-Tg-rg-MP0490-Ab-1/ GM-Tg-rg-MP0490-Ab-2;
GM-Tg-mg-MP0490-Ab-1/ GM-Tg-mg-MP0490-Ab-2; GM-Tg-cynog-MP0490-Ab-1/ GM-Tg-cynog-MP0490-Ab-2;
GM-Tg-felg-MP0490-Ab-1/ GM-Tg-felg-MP0490-Ab-2; GM-Tg-cang-MP0490-Ab-1/ GM-Tg-cang-MP0490-Ab-2;
GM-Tg-bovg-MP0490-Ab-1/ GM-Tg-bovg-MP0490-Ab-2; GM-Tg-equg-MP0490-Ab-1/ GM-Tg-equg-MP0490-Ab-2
Products NameAnti-GPC1 monoclonal antibody
Formatmab
Target NameGPC1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-GPC1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species GPC1/ glypican VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0490
    Target NameGPC1
    Gene ID2817,14733,58920,698326,486197,101094122,518114,100067268
    Gene Symbol and Synonymsglypican,GPC1,HSPG M12,HSPGM12
    Uniprot AccessionP35052,P35053,G3X745
    Uniprot Entry NameGPC1_HUMAN,GPC1_RAT,GPC1_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000063660
    Target ClassificationN/A

    The target: GPC1, gene name: GPC1, also named as glypican. Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage.  These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.