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Anti-FZD8/ FZ-8/ hFZ8 monoclonal antibody
Anti-FZD8/ FZ-8/ hFZ8 antibody for FACS & in-vivo assay
Go to FZD8/FZD8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0466-Ab-1/ GM-Tg-hg-MP0466-Ab-2 | Anti-Human FZD8 monoclonal antibody | Human |
| GM-Tg-rg-MP0466-Ab-1/ GM-Tg-rg-MP0466-Ab-2 | Anti-Rat FZD8 monoclonal antibody | Rat |
| GM-Tg-mg-MP0466-Ab-1/ GM-Tg-mg-MP0466-Ab-2 | Anti-Mouse FZD8 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0466-Ab-1/ GM-Tg-cynog-MP0466-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FZD8 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0466-Ab-1/ GM-Tg-felg-MP0466-Ab-2 | Anti-Feline FZD8 monoclonal antibody | Feline |
| GM-Tg-cang-MP0466-Ab-1/ GM-Tg-cang-MP0466-Ab-2 | Anti-Canine FZD8 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0466-Ab-1/ GM-Tg-bovg-MP0466-Ab-2 | Anti-Bovine FZD8 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0466-Ab-1/ GM-Tg-equg-MP0466-Ab-2 | Anti-Equine FZD8 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0466-Ab-1/ GM-Tg-hg-MP0466-Ab-2; GM-Tg-rg-MP0466-Ab-1/ GM-Tg-rg-MP0466-Ab-2; GM-Tg-mg-MP0466-Ab-1/ GM-Tg-mg-MP0466-Ab-2; GM-Tg-cynog-MP0466-Ab-1/ GM-Tg-cynog-MP0466-Ab-2; GM-Tg-felg-MP0466-Ab-1/ GM-Tg-felg-MP0466-Ab-2; GM-Tg-cang-MP0466-Ab-1/ GM-Tg-cang-MP0466-Ab-2; GM-Tg-bovg-MP0466-Ab-1/ GM-Tg-bovg-MP0466-Ab-2; GM-Tg-equg-MP0466-Ab-1/ GM-Tg-equg-MP0466-Ab-2 |
| Products Name | Anti-FZD8 monoclonal antibody |
| Format | mab |
| Target Name | FZD8 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-FZD8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species FZD8/ FZ-8/ hFZ8 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP0466-Ag-1 | frizzled class receptor 8 (FZD8) protein |
Target information
| Target ID | GM-MP0466 |
| Target Name | FZD8 |
| Gene ID | 8325,14370,364754,708368,487073,101101229,616913,111771171 |
| Gene Symbol and Synonyms | FZ-8,Fz8,FZD8,hFZ8 |
| Uniprot Accession | Q9H461,Q498S8 |
| Uniprot Entry Name | FZD8_HUMAN,FZD8_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000177283 |
| Target Classification | N/A |
The target: FZD8, gene name: FZD8, also named as FZ-8, hFZ8. This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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