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Anti-EFNB2/ EPLG5/ HTKL monoclonal antibody
Anti-EFNB2/ EPLG5/ HTKL antibody for FACS & in-vivo assay
Go to EFNB2/EFNB2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0398-Ab-1/ GM-Tg-hg-MP0398-Ab-2 | Anti-Human EFNB2 monoclonal antibody | Human |
| GM-Tg-rg-MP0398-Ab-1/ GM-Tg-rg-MP0398-Ab-2 | Anti-Rat EFNB2 monoclonal antibody | Rat |
| GM-Tg-mg-MP0398-Ab-1/ GM-Tg-mg-MP0398-Ab-2 | Anti-Mouse EFNB2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0398-Ab-1/ GM-Tg-cynog-MP0398-Ab-2 | Anti-Cynomolgus/ Rhesus macaque EFNB2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0398-Ab-1/ GM-Tg-felg-MP0398-Ab-2 | Anti-Feline EFNB2 monoclonal antibody | Feline |
| GM-Tg-cang-MP0398-Ab-1/ GM-Tg-cang-MP0398-Ab-2 | Anti-Canine EFNB2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0398-Ab-1/ GM-Tg-bovg-MP0398-Ab-2 | Anti-Bovine EFNB2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0398-Ab-1/ GM-Tg-equg-MP0398-Ab-2 | Anti-Equine EFNB2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0398-Ab-1/ GM-Tg-hg-MP0398-Ab-2; GM-Tg-rg-MP0398-Ab-1/ GM-Tg-rg-MP0398-Ab-2; GM-Tg-mg-MP0398-Ab-1/ GM-Tg-mg-MP0398-Ab-2; GM-Tg-cynog-MP0398-Ab-1/ GM-Tg-cynog-MP0398-Ab-2; GM-Tg-felg-MP0398-Ab-1/ GM-Tg-felg-MP0398-Ab-2; GM-Tg-cang-MP0398-Ab-1/ GM-Tg-cang-MP0398-Ab-2; GM-Tg-bovg-MP0398-Ab-1/ GM-Tg-bovg-MP0398-Ab-2; GM-Tg-equg-MP0398-Ab-1/ GM-Tg-equg-MP0398-Ab-2 |
| Products Name | Anti-EFNB2 monoclonal antibody |
| Format | mab |
| Target Name | EFNB2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-EFNB2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species EFNB2/ EPLG5/ HTKL VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLV000472 | Norway rat Efnb2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001085 | mouse Efnb2 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000472 | Norway rat Efnb2 Lentivirus particle |
| ORF Viral Vector | vGMLPm001085 | mouse Efnb2 Lentivirus particle |
Target information
| Target ID | GM-MP0398 |
| Target Name | EFNB2 |
| Gene ID | 1948,13642,306636,711288,611745,100135769,100139818,100064730 |
| Gene Symbol and Synonyms | EFNB2,ELF-2,ephrin-B2,Epl5,EPLG5,Htk-L,HTKL,LERK-5,LERK5,NLERK-1 |
| Uniprot Accession | P52799 |
| Uniprot Entry Name | EFNB2_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000125266 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: EFNB2, gene name: EFNB2, also named as EPLG5, HTKL, Htk-L, LERK5. This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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