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Anti-EDA/ ECTD1/ ED1 monoclonal antibody
Anti-EDA/ ECTD1/ ED1 antibody for FACS & in-vivo assay
Go to EDA/EDA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0389-Ab-1/ GM-Tg-hg-MP0389-Ab-2 | Anti-Human EDA monoclonal antibody | Human |
| GM-Tg-rg-MP0389-Ab-1/ GM-Tg-rg-MP0389-Ab-2 | Anti-Rat EDA monoclonal antibody | Rat |
| GM-Tg-mg-MP0389-Ab-1/ GM-Tg-mg-MP0389-Ab-2 | Anti-Mouse EDA monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0389-Ab-1/ GM-Tg-cynog-MP0389-Ab-2 | Anti-Cynomolgus/ Rhesus macaque EDA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0389-Ab-1/ GM-Tg-felg-MP0389-Ab-2 | Anti-Feline EDA monoclonal antibody | Feline |
| GM-Tg-cang-MP0389-Ab-1/ GM-Tg-cang-MP0389-Ab-2 | Anti-Canine EDA monoclonal antibody | Canine |
| GM-Tg-bovg-MP0389-Ab-1/ GM-Tg-bovg-MP0389-Ab-2 | Anti-Bovine EDA monoclonal antibody | Bovine |
| GM-Tg-equg-MP0389-Ab-1/ GM-Tg-equg-MP0389-Ab-2 | Anti-Equine EDA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0389-Ab-1/ GM-Tg-hg-MP0389-Ab-2; GM-Tg-rg-MP0389-Ab-1/ GM-Tg-rg-MP0389-Ab-2; GM-Tg-mg-MP0389-Ab-1/ GM-Tg-mg-MP0389-Ab-2; GM-Tg-cynog-MP0389-Ab-1/ GM-Tg-cynog-MP0389-Ab-2; GM-Tg-felg-MP0389-Ab-1/ GM-Tg-felg-MP0389-Ab-2; GM-Tg-cang-MP0389-Ab-1/ GM-Tg-cang-MP0389-Ab-2; GM-Tg-bovg-MP0389-Ab-1/ GM-Tg-bovg-MP0389-Ab-2; GM-Tg-equg-MP0389-Ab-1/ GM-Tg-equg-MP0389-Ab-2 |
| Products Name | Anti-EDA monoclonal antibody |
| Format | mab |
| Target Name | EDA |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-EDA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species EDA/ ECTD1/ ED1 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP0389-Ag-1 | ectodysplasin A (EDA) protein |
| ORF Viral Vector | pGMLPm003999 | mouse Eda Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003999 | mouse Eda Lentivirus particle |
Target information
| Target ID | GM-MP0389 |
| Target Name | EDA |
| Gene ID | 1896,13607,302424,694110,491935,101100283,616179,100065499 |
| Gene Symbol and Synonyms | ECTD1,ED1,ED1-A1,ED1-A2,EDA,EDA-A1,EDA-A2,EDA1,EDA2,HED,HED1,ODT1,RGD1563178,STHAGX1,Ta,tabby,TNLG7C,XHED,XLHED |
| Uniprot Accession | Q92838,Q9BEG5 |
| Uniprot Entry Name | EDA_HUMAN,EDA_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000158813 |
| Target Classification | N/A |
The target: EDA, gene name: EDA, also named as ECTD1, ED1, ED1-A1, ED1-A2-A1, EDA-A2, EDA1, EDA2, HED, HED1, ODT1, STHAGX1, TNLG7C, XHED, XLHED, EDA. The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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