Anti-ECSCR/ ARIA/ ECSM2 monoclonal antibody

Anti-ECSCR/ ARIA/ ECSM2 antibody for FACS & in-vivo assay

Target products collectionGo to ECSCR/ECSCR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0388-Ab-1/ GM-Tg-hg-MP0388-Ab-2Anti-Human ECSCR monoclonal antibodyHuman
GM-Tg-rg-MP0388-Ab-1/ GM-Tg-rg-MP0388-Ab-2Anti-Rat ECSCR monoclonal antibodyRat
GM-Tg-mg-MP0388-Ab-1/ GM-Tg-mg-MP0388-Ab-2Anti-Mouse ECSCR monoclonal antibodyMouse
GM-Tg-cynog-MP0388-Ab-1/ GM-Tg-cynog-MP0388-Ab-2Anti-Cynomolgus/ Rhesus macaque ECSCR monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0388-Ab-1/ GM-Tg-felg-MP0388-Ab-2Anti-Feline ECSCR monoclonal antibodyFeline
GM-Tg-cang-MP0388-Ab-1/ GM-Tg-cang-MP0388-Ab-2Anti-Canine ECSCR monoclonal antibodyCanine
GM-Tg-bovg-MP0388-Ab-1/ GM-Tg-bovg-MP0388-Ab-2Anti-Bovine ECSCR monoclonal antibodyBovine
GM-Tg-equg-MP0388-Ab-1/ GM-Tg-equg-MP0388-Ab-2Anti-Equine ECSCR monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0388-Ab-1/ GM-Tg-hg-MP0388-Ab-2; GM-Tg-rg-MP0388-Ab-1/ GM-Tg-rg-MP0388-Ab-2;
GM-Tg-mg-MP0388-Ab-1/ GM-Tg-mg-MP0388-Ab-2; GM-Tg-cynog-MP0388-Ab-1/ GM-Tg-cynog-MP0388-Ab-2;
GM-Tg-felg-MP0388-Ab-1/ GM-Tg-felg-MP0388-Ab-2; GM-Tg-cang-MP0388-Ab-1/ GM-Tg-cang-MP0388-Ab-2;
GM-Tg-bovg-MP0388-Ab-1/ GM-Tg-bovg-MP0388-Ab-2; GM-Tg-equg-MP0388-Ab-1/ GM-Tg-equg-MP0388-Ab-2
Products NameAnti-ECSCR monoclonal antibody
Formatmab
Target NameECSCR
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ECSCR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ECSCR/ ARIA/ ECSM2 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0388
    Target NameECSCR
    Gene ID641700,68545,689248,100428408,478026,101090483,511765,100072509
    Gene Symbol and Synonyms1110006O17Rik,ARIA,ECSCR,Ecscr-ps1,ECSM2
    Uniprot AccessionQ19T08,Q2KIX5
    Uniprot Entry NameECSCR_HUMAN,ECSCR_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000249751
    Target ClassificationN/A

    The target: ECSCR, gene name: ECSCR, also named as ARIA, ECSM2. The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it is involved in cell shape changes and EGF-induced cell migration. It can enhance the activation of vascular endothelial growth factor receptor-2/kinase insert domain receptor and also promote the proteolysis of internalized kinase insert domain receptor. This gene may play a role in angiogenesis-related diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.