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Anti-CEACAM8/CD66b monoclonal antibody
Anti-CEACAM8/CD66b antibody for FACS & in-vivo assay
Go to CEACAM8/CEACAM8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0250-Ab-1/ GM-Tg-hg-MP0250-Ab-2 | Anti-Human CEACAM8 monoclonal antibody | Human |
| GM-Tg-hg-MP0250-Ab-3/ GM-Tg-hg-MP0250-Ab-4 | Anti-Human CEACAM8 monoclonal antibody | Human |
| GM-Tg-rg-MP0250-Ab-1/ GM-Tg-rg-MP0250-Ab-2 | Anti-Rat CEACAM8 monoclonal antibody | Rat |
| GM-Tg-mg-MP0250-Ab-1/ GM-Tg-mg-MP0250-Ab-2 | Anti-Mouse CEACAM8 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0250-Ab-1/ GM-Tg-cynog-MP0250-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CEACAM8 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0250-Ab-1/ GM-Tg-felg-MP0250-Ab-2 | Anti-Feline CEACAM8 monoclonal antibody | Feline |
| GM-Tg-cang-MP0250-Ab-1/ GM-Tg-cang-MP0250-Ab-2 | Anti-Canine CEACAM8 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0250-Ab-1/ GM-Tg-bovg-MP0250-Ab-2 | Anti-Bovine CEACAM8 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0250-Ab-1/ GM-Tg-equg-MP0250-Ab-2 | Anti-Equine CEACAM8 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0250-Ab-1/ GM-Tg-hg-MP0250-Ab-2; GM-Tg-hg-MP0250-Ab-3/ GM-Tg-hg-MP0250-Ab-4; GM-Tg-rg-MP0250-Ab-1/ GM-Tg-rg-MP0250-Ab-2; GM-Tg-mg-MP0250-Ab-1/ GM-Tg-mg-MP0250-Ab-2; GM-Tg-cynog-MP0250-Ab-1/ GM-Tg-cynog-MP0250-Ab-2; GM-Tg-felg-MP0250-Ab-1/ GM-Tg-felg-MP0250-Ab-2; GM-Tg-cang-MP0250-Ab-1/ GM-Tg-cang-MP0250-Ab-2; GM-Tg-bovg-MP0250-Ab-1/ GM-Tg-bovg-MP0250-Ab-2; GM-Tg-equg-MP0250-Ab-1/ GM-Tg-equg-MP0250-Ab-2 |
| Products Name | Anti-CEACAM8 monoclonal antibody |
| Format | mab |
| Target Name | CEACAM8/CD66b |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse/Human |
| CH1+2+3 Isotype (Receptor identification) |
IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CEACAM8/CD66b benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-INN-756 | Pre-Made Besilesomab Biosimilar, Radiolabelled Antibody, Anti-Ceacam8/NCA-95 Antibody: Anti-CD66b/CD67/CGM6 therapeutic antibody |
| Target Antigen | Products Developing | Multi-species CEAM8/ CEACAM8/ CD66b VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0250 |
| Target Name | CEACAM8/CD66b |
| Gene ID | 1088 |
| Gene Symbol and Synonyms | CEACAM8, CD66b,Cell adhesion molecule CEACAM8,CD67 antigen; Carcinoembryonic antigen CGM6; Carcinoembryonic antigen-related cell adhesion molecule 8 (CEA cell adhesion molecule 8); Non-specific cross-reacting antigen NCA-95,CD67,CGM6,CD66b,NCA-95 |
| Uniprot Accession | P31997 |
| Uniprot Entry Name | CEAM8_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index |
| Disease | Cancer |
| Gene Ensembl | ENSG00000124469 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: CEACAM8, gene name: CEACAM8, also named as CD66b, CD67, CGM6, NCA-95. Enables protein heterodimerization activity. Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Located in cell surface and extracellular space. Biomarker of severe acute respiratory syndrome. [provided by Alliance of Genome Resources, Apr 2022].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM's Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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