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Anti-CD81/ CVID6/ S5.7 monoclonal antibody
Anti-CD81/ CVID6/ S5.7 antibody for FACS & in-vivo assay
Go to CD81/CD81 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0217-Ab-1/ GM-Tg-hg-MP0217-Ab-2 | Anti-Human CD81 monoclonal antibody | Human |
| GM-Tg-rg-MP0217-Ab-1/ GM-Tg-rg-MP0217-Ab-2 | Anti-Rat CD81 monoclonal antibody | Rat |
| GM-Tg-mg-MP0217-Ab-1/ GM-Tg-mg-MP0217-Ab-2 | Anti-Mouse CD81 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0217-Ab-1/ GM-Tg-cynog-MP0217-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CD81 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0217-Ab-1/ GM-Tg-felg-MP0217-Ab-2 | Anti-Feline CD81 monoclonal antibody | Feline |
| GM-Tg-cang-MP0217-Ab-1/ GM-Tg-cang-MP0217-Ab-2 | Anti-Canine CD81 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0217-Ab-1/ GM-Tg-bovg-MP0217-Ab-2 | Anti-Bovine CD81 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0217-Ab-1/ GM-Tg-equg-MP0217-Ab-2 | Anti-Equine CD81 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0217-Ab-1/ GM-Tg-hg-MP0217-Ab-2; GM-Tg-rg-MP0217-Ab-1/ GM-Tg-rg-MP0217-Ab-2; GM-Tg-mg-MP0217-Ab-1/ GM-Tg-mg-MP0217-Ab-2; GM-Tg-cynog-MP0217-Ab-1/ GM-Tg-cynog-MP0217-Ab-2; GM-Tg-felg-MP0217-Ab-1/ GM-Tg-felg-MP0217-Ab-2; GM-Tg-cang-MP0217-Ab-1/ GM-Tg-cang-MP0217-Ab-2; GM-Tg-bovg-MP0217-Ab-1/ GM-Tg-bovg-MP0217-Ab-2; GM-Tg-equg-MP0217-Ab-1/ GM-Tg-equg-MP0217-Ab-2 |
| Products Name | Anti-CD81 monoclonal antibody |
| Format | mab |
| Target Name | CD81 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CD81 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CD81/ CVID6/ S5.7 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLV000243 | human CD81 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000243 | human CD81 Lentivirus particle |
| ORF Viral Vector | pGMLPm001913 | mouse Cd81 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001913 | mouse Cd81 Lentivirus particle |
Target information
| Target ID | GM-MP0217 |
| Target Name | CD81 |
| Gene ID | 975,12520,25621,704961,611606,101093144,511435,100060480 |
| Gene Symbol and Synonyms | CD81,CVID6,S5.7,Tapa-1,TAPA1,TSPAN28 |
| Uniprot Accession | P60033,Q62745,Q3ZCD0 |
| Uniprot Entry Name | CD81_HUMAN,CD81_RAT,CD81_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000110651 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: CD81, gene name: CD81, also named as CVID6, S5.7, TAPA1, TSPAN28. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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