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Anti-BTC monoclonal antibody
Anti-BTC antibody for FACS & in-vivo assay
Go to BTC/BTC products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0142-Ab-1/ GM-Tg-hg-MP0142-Ab-2 | Anti-Human BTC monoclonal antibody | Human |
| GM-Tg-rg-MP0142-Ab-1/ GM-Tg-rg-MP0142-Ab-2 | Anti-Rat BTC monoclonal antibody | Rat |
| GM-Tg-mg-MP0142-Ab-1/ GM-Tg-mg-MP0142-Ab-2 | Anti-Mouse BTC monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0142-Ab-1/ GM-Tg-cynog-MP0142-Ab-2 | Anti-Cynomolgus/ Rhesus macaque BTC monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0142-Ab-1/ GM-Tg-felg-MP0142-Ab-2 | Anti-Feline BTC monoclonal antibody | Feline |
| GM-Tg-cang-MP0142-Ab-1/ GM-Tg-cang-MP0142-Ab-2 | Anti-Canine BTC monoclonal antibody | Canine |
| GM-Tg-bovg-MP0142-Ab-1/ GM-Tg-bovg-MP0142-Ab-2 | Anti-Bovine BTC monoclonal antibody | Bovine |
| GM-Tg-equg-MP0142-Ab-1/ GM-Tg-equg-MP0142-Ab-2 | Anti-Equine BTC monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0142-Ab-1/ GM-Tg-hg-MP0142-Ab-2; GM-Tg-rg-MP0142-Ab-1/ GM-Tg-rg-MP0142-Ab-2; GM-Tg-mg-MP0142-Ab-1/ GM-Tg-mg-MP0142-Ab-2; GM-Tg-cynog-MP0142-Ab-1/ GM-Tg-cynog-MP0142-Ab-2; GM-Tg-felg-MP0142-Ab-1/ GM-Tg-felg-MP0142-Ab-2; GM-Tg-cang-MP0142-Ab-1/ GM-Tg-cang-MP0142-Ab-2; GM-Tg-bovg-MP0142-Ab-1/ GM-Tg-bovg-MP0142-Ab-2; GM-Tg-equg-MP0142-Ab-1/ GM-Tg-equg-MP0142-Ab-2 |
| Products Name | Anti-BTC monoclonal antibody |
| Format | mab |
| Target Name | BTC |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-BTC benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species BTC VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP0142-Ag-1 | betacellulin (BTC) protein |
| ORF Viral Vector | vGMLP003424 | human BTC Lentivirus particle |
| ORF Viral Vector | vGMLP003911 | human BTC Lentivirus particle |
| ORF Viral Vector | pGMLP003424 | human BTC Lentivirus plasmid |
| ORF Viral Vector | pGMLP003911 | human BTC Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000033 | mouse Btc Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000033 | mouse Btc Lentivirus particle |
Target information
| Target ID | GM-MP0142 |
| Target Name | BTC |
| Gene ID | 685,12223,64022,702178,482682,101092850,280737,100056845 |
| Gene Symbol and Synonyms | Bcn,BTC |
| Uniprot Accession | P35070,Q9TTC5 |
| Uniprot Entry Name | BTC_HUMAN,BTC_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000174808 |
| Target Classification | N/A |
The target: BTC, gene name: BTC, also named as . This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients. [provided by RefSeq, Nov 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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