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Anti-AT2B1/ ATP2B1/ PMCA1 monoclonal antibody
Anti-AT2B1/ ATP2B1/ PMCA1 antibody for FACS & in-vivo assay
Go to ATP2B1/ATP2B1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0103-Ab-1/ GM-Tg-hg-MP0103-Ab-2 | Anti-Human ATP2B1 monoclonal antibody | Human |
| GM-Tg-rg-MP0103-Ab-1/ GM-Tg-rg-MP0103-Ab-2 | Anti-Rat ATP2B1 monoclonal antibody | Rat |
| GM-Tg-mg-MP0103-Ab-1/ GM-Tg-mg-MP0103-Ab-2 | Anti-Mouse ATP2B1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0103-Ab-1/ GM-Tg-cynog-MP0103-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ATP2B1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0103-Ab-1/ GM-Tg-felg-MP0103-Ab-2 | Anti-Feline ATP2B1 monoclonal antibody | Feline |
| GM-Tg-cang-MP0103-Ab-1/ GM-Tg-cang-MP0103-Ab-2 | Anti-Canine ATP2B1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0103-Ab-1/ GM-Tg-bovg-MP0103-Ab-2 | Anti-Bovine ATP2B1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0103-Ab-1/ GM-Tg-equg-MP0103-Ab-2 | Anti-Equine ATP2B1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0103-Ab-1/ GM-Tg-hg-MP0103-Ab-2; GM-Tg-rg-MP0103-Ab-1/ GM-Tg-rg-MP0103-Ab-2; GM-Tg-mg-MP0103-Ab-1/ GM-Tg-mg-MP0103-Ab-2; GM-Tg-cynog-MP0103-Ab-1/ GM-Tg-cynog-MP0103-Ab-2; GM-Tg-felg-MP0103-Ab-1/ GM-Tg-felg-MP0103-Ab-2; GM-Tg-cang-MP0103-Ab-1/ GM-Tg-cang-MP0103-Ab-2; GM-Tg-bovg-MP0103-Ab-1/ GM-Tg-bovg-MP0103-Ab-2; GM-Tg-equg-MP0103-Ab-1/ GM-Tg-equg-MP0103-Ab-2 |
| Products Name | Anti-ATP2B1 monoclonal antibody |
| Format | mab |
| Target Name | ATP2B1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ATP2B1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species AT2B1/ ATP2B1/ PMCA1 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0103 |
| Target Name | ATP2B1 |
| Gene ID | 490,67972,29598,709102,403480,101098392,282641,100051636 |
| Gene Symbol and Synonyms | 2810442I22Rik,ATP2B1,E130111D10Rik,MRD66,PMCA,PMCA1,Pmca1a,Pmca1b,Pmca1c,PMCA1kb |
| Uniprot Accession | P20020,P11505 |
| Uniprot Entry Name | AT2B1_HUMAN,AT2B1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000070961 |
| Target Classification | N/A |
The target: ATP2B1, gene name: ATP2B1, also named as PMCA1, PMCA1kb. The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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