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Anti-ACKR4/ CC-CKR-11/ CCBP2 monoclonal antibody
Anti-ACKR4/ CC-CKR-11/ CCBP2 antibody for FACS & in-vivo assay
Go to ACKR4/ACKR4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0020-Ab-1/ GM-Tg-hg-MP0020-Ab-2 | Anti-Human ACKR4 monoclonal antibody | Human |
| GM-Tg-rg-MP0020-Ab-1/ GM-Tg-rg-MP0020-Ab-2 | Anti-Rat ACKR4 monoclonal antibody | Rat |
| GM-Tg-mg-MP0020-Ab-1/ GM-Tg-mg-MP0020-Ab-2 | Anti-Mouse ACKR4 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0020-Ab-1/ GM-Tg-cynog-MP0020-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ACKR4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0020-Ab-1/ GM-Tg-felg-MP0020-Ab-2 | Anti-Feline ACKR4 monoclonal antibody | Feline |
| GM-Tg-cang-MP0020-Ab-1/ GM-Tg-cang-MP0020-Ab-2 | Anti-Canine ACKR4 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0020-Ab-1/ GM-Tg-bovg-MP0020-Ab-2 | Anti-Bovine ACKR4 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0020-Ab-1/ GM-Tg-equg-MP0020-Ab-2 | Anti-Equine ACKR4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0020-Ab-1/ GM-Tg-hg-MP0020-Ab-2; GM-Tg-rg-MP0020-Ab-1/ GM-Tg-rg-MP0020-Ab-2; GM-Tg-mg-MP0020-Ab-1/ GM-Tg-mg-MP0020-Ab-2; GM-Tg-cynog-MP0020-Ab-1/ GM-Tg-cynog-MP0020-Ab-2; GM-Tg-felg-MP0020-Ab-1/ GM-Tg-felg-MP0020-Ab-2; GM-Tg-cang-MP0020-Ab-1/ GM-Tg-cang-MP0020-Ab-2; GM-Tg-bovg-MP0020-Ab-1/ GM-Tg-bovg-MP0020-Ab-2; GM-Tg-equg-MP0020-Ab-1/ GM-Tg-equg-MP0020-Ab-2 |
| Products Name | Anti-ACKR4 monoclonal antibody |
| Format | mab |
| Target Name | ACKR4 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ACKR4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ACKR4/ CC-CKR-11/ CCBP2 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP0020-Ag-1 | atypical chemokine receptor 4 (CCRL1) protein |
Target information
| Target ID | GM-MP0020 |
| Target Name | ACKR4 |
| Gene ID | 51554,252837,685243,717701,100856510,101088872,281672,100146120 |
| Gene Symbol and Synonyms | A630091E18Rik,ACKR4,CC-CKR-11,CCBP2,CCR-11,CCR10,CCR11,CCRL1,CCX CKR,CCX-CKR,CCX-CKR1,CKR-11,Cmkbrl1,PPR1,VSHK1 |
| Uniprot Accession | Q9NPB9,P35350 |
| Uniprot Entry Name | ACKR4_HUMAN,ACKR4_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000129048 |
| Target Classification | GPCR |
The target: ACKR4, gene name: ACKR4, also named as CC-CKR-11, CCBP2, CCR-11, CCR10, CCR11, CCRL1, CCX CKR, CCX-CKR, CKR-11, PPR1, VSHK1. The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. A pseudogene of this gene is found on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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