Anti-MRP5/ ABCC5/ ABC33 monoclonal antibody

Anti-MRP5/ ABCC5/ ABC33 antibody for FACS & in-vivo assay

Target products collectionGo to ABCC5/ABCC5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0013-Ab-1/ GM-Tg-hg-MP0013-Ab-2Anti-Human ABCC5 monoclonal antibodyHuman
GM-Tg-rg-MP0013-Ab-1/ GM-Tg-rg-MP0013-Ab-2Anti-Rat ABCC5 monoclonal antibodyRat
GM-Tg-mg-MP0013-Ab-1/ GM-Tg-mg-MP0013-Ab-2Anti-Mouse ABCC5 monoclonal antibodyMouse
GM-Tg-cynog-MP0013-Ab-1/ GM-Tg-cynog-MP0013-Ab-2Anti-Cynomolgus/ Rhesus macaque ABCC5 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0013-Ab-1/ GM-Tg-felg-MP0013-Ab-2Anti-Feline ABCC5 monoclonal antibodyFeline
GM-Tg-cang-MP0013-Ab-1/ GM-Tg-cang-MP0013-Ab-2Anti-Canine ABCC5 monoclonal antibodyCanine
GM-Tg-bovg-MP0013-Ab-1/ GM-Tg-bovg-MP0013-Ab-2Anti-Bovine ABCC5 monoclonal antibodyBovine
GM-Tg-equg-MP0013-Ab-1/ GM-Tg-equg-MP0013-Ab-2Anti-Equine ABCC5 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0013-Ab-1/ GM-Tg-hg-MP0013-Ab-2; GM-Tg-rg-MP0013-Ab-1/ GM-Tg-rg-MP0013-Ab-2;
GM-Tg-mg-MP0013-Ab-1/ GM-Tg-mg-MP0013-Ab-2; GM-Tg-cynog-MP0013-Ab-1/ GM-Tg-cynog-MP0013-Ab-2;
GM-Tg-felg-MP0013-Ab-1/ GM-Tg-felg-MP0013-Ab-2; GM-Tg-cang-MP0013-Ab-1/ GM-Tg-cang-MP0013-Ab-2;
GM-Tg-bovg-MP0013-Ab-1/ GM-Tg-bovg-MP0013-Ab-2; GM-Tg-equg-MP0013-Ab-1/ GM-Tg-equg-MP0013-Ab-2
Products NameAnti-ABCC5 monoclonal antibody
Formatmab
Target NameABCC5
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ABCC5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species MRP5/ ABCC5/ ABC33 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMAD000586human ABCC5 Adenovirus plasmid
    ORF Viral VectorvGMAD000586human ABCC5 Adenovirus particle


    Target information

    Target IDGM-MP0013
    Target NameABCC5
    Gene ID10057,27416,116721,704326,478648,101090542,511769,100066941
    Gene Symbol and Synonyms2900011L11Rik,ABC33,ABCC5,Abcc5a,Abcc5b,EST277145,MOAT-C,MOATC,MRP5,pABC11,SMRP
    Uniprot AccessionO15440,Q9QYM0
    Uniprot Entry NameMRP5_HUMAN,MRP5_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseCancer
    Gene EnsemblENSG00000114770
    Target ClassificationTumor-associated antigen (TAA)

    The target: ABCC5, gene name: ABCC5, also named as ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].



    About Gmab

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    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.