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Anti-CHD8 monoclonal antibody
Pre-made anti-CHD8 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to CHD8/CHD8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2428-Ab-1/ GM-Tg-hg-IP2428-Ab-2 | Anti-Human CHD8 monoclonal antibody | Human |
| GM-Tg-rg-IP2428-Ab-1/ GM-Tg-rg-IP2428-Ab-2 | Anti-Rat CHD8 monoclonal antibody | Rat |
| GM-Tg-mg-IP2428-Ab-1/ GM-Tg-mg-IP2428-Ab-2 | Anti-Mouse CHD8 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2428-Ab-1/ GM-Tg-cynog-IP2428-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CHD8 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2428-Ab-1/ GM-Tg-felg-IP2428-Ab-2 | Anti-Feline CHD8 monoclonal antibody | Feline |
| GM-Tg-cang-IP2428-Ab-1/ GM-Tg-cang-IP2428-Ab-2 | Anti-Canine CHD8 monoclonal antibody | Canine |
| GM-Tg-bovg-IP2428-Ab-1/ GM-Tg-bovg-IP2428-Ab-2 | Anti-Bovine CHD8 monoclonal antibody | Bovine |
| GM-Tg-equg-IP2428-Ab-1/ GM-Tg-equg-IP2428-Ab-2 | Anti-Equine CHD8 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2428-Ab-1/ GM-Tg-hg-IP2428-Ab-2; GM-Tg-rg-IP2428-Ab-1/ GM-Tg-rg-IP2428-Ab-2; GM-Tg-mg-IP2428-Ab-1/ GM-Tg-mg-IP2428-Ab-2; GM-Tg-cynog-IP2428-Ab-1/ GM-Tg-cynog-IP2428-Ab-2; GM-Tg-felg-IP2428-Ab-1/ GM-Tg-felg-IP2428-Ab-2; GM-Tg-cang-IP2428-Ab-1/ GM-Tg-cang-IP2428-Ab-2; GM-Tg-bovg-IP2428-Ab-1/ GM-Tg-bovg-IP2428-Ab-2; GM-Tg-equg-IP2428-Ab-1/ GM-Tg-equg-IP2428-Ab-2 |
| Products Name | Anti-CHD8 monoclonal antibody |
| Format | mab |
| Target Name | CHD8 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-CHD8 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2428-Ag-1 | Recombinant multi-species CHD8/ AUTS18/ HELSNF1 protein |
Target information
| Target ID | GM-IP2428 |
| Target Name | CHD8 |
| Gene ID | 57680,67772,65027,708169,475401,101097402,507111,100059337 |
| Gene Symbol and Synonyms | 5830451P18Rik,AUTS18,Chd-8,CHD8,Duplin,HELSNF1,IDDAM,mKIAA1564 |
| Uniprot Accession | Q9HCK8,Q9JIX5 |
| Uniprot Entry Name | CHD8_HUMAN,CHD8_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000100888 |
| Target Classification | N/A |
The target: CHD8, gene name: CHD8, also named as AUTS18, HELSNF1. This gene encodes a member of the chromodomain-helicase-DNA binding protein family, which is characterized by a SNF2-like domain and two chromatin organization modifier domains. The encoded protein also contains brahma and kismet domains, which are common to the subfamily of chromodomain-helicase-DNA binding proteins to which this protein belongs. This gene has been shown to function in several processes that include transcriptional regulation, epigenetic remodeling, promotion of cell proliferation, and regulation of RNA synthesis. Allelic variants of this gene are associated with autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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