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Anti-™EM123 monoclonal antibody
Pre-made anti-™EM123 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to ™EM123/™EM123 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1966-Ab-1/ GM-Tg-hg-IP1966-Ab-2 | Anti-Human ™EM123 monoclonal antibody | Human |
| GM-Tg-rg-IP1966-Ab-1/ GM-Tg-rg-IP1966-Ab-2 | Anti-Rat ™EM123 monoclonal antibody | Rat |
| GM-Tg-mg-IP1966-Ab-1/ GM-Tg-mg-IP1966-Ab-2 | Anti-Mouse ™EM123 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1966-Ab-1/ GM-Tg-cynog-IP1966-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ™EM123 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1966-Ab-1/ GM-Tg-felg-IP1966-Ab-2 | Anti-Feline ™EM123 monoclonal antibody | Feline |
| GM-Tg-cang-IP1966-Ab-1/ GM-Tg-cang-IP1966-Ab-2 | Anti-Canine ™EM123 monoclonal antibody | Canine |
| GM-Tg-bovg-IP1966-Ab-1/ GM-Tg-bovg-IP1966-Ab-2 | Anti-Bovine ™EM123 monoclonal antibody | Bovine |
| GM-Tg-equg-IP1966-Ab-1/ GM-Tg-equg-IP1966-Ab-2 | Anti-Equine ™EM123 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1966-Ab-1/ GM-Tg-hg-IP1966-Ab-2; GM-Tg-rg-IP1966-Ab-1/ GM-Tg-rg-IP1966-Ab-2; GM-Tg-mg-IP1966-Ab-1/ GM-Tg-mg-IP1966-Ab-2; GM-Tg-cynog-IP1966-Ab-1/ GM-Tg-cynog-IP1966-Ab-2; GM-Tg-felg-IP1966-Ab-1/ GM-Tg-felg-IP1966-Ab-2; GM-Tg-cang-IP1966-Ab-1/ GM-Tg-cang-IP1966-Ab-2; GM-Tg-bovg-IP1966-Ab-1/ GM-Tg-bovg-IP1966-Ab-2; GM-Tg-equg-IP1966-Ab-1/ GM-Tg-equg-IP1966-Ab-2 |
| Products Name | Anti-™EM123 monoclonal antibody |
| Format | mab |
| Target Name | ™EM123 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-™EM123 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1966-Ag-1 | Recombinant multi-species PORIM/ ™EM123/ KCT3 protein |
| ORF Viral Vector | pGMLP002544 | human ™EM123 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002544 | human ™EM123 Lentivirus particle |
| ORF Viral Vector | pGMLPm001893 | mouse Tmem123 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001893 | mouse Tmem123 Lentivirus particle |
Target information
| Target ID | GM-IP1966 |
| Target Name | ™EM123 |
| Gene ID | 114908,71929,363013,702833,100856041,102902402,100300021,100068925 |
| Gene Symbol and Synonyms | 2310075C12Rik,KCT3,PORIMIN,PORMIN,RGD1305625,™EM123 |
| Uniprot Accession | Q8N131,Q5HZB0 |
| Uniprot Entry Name | PORIM_HUMAN,PORIM_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000152558 |
| Target Classification | N/A |
The target: ™EM123, gene name: ™EM123, also named as KCT3, PORIMIN, PORMIN. This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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