Anti-PBXIP1 monoclonal antibody

Pre-made anti-PBXIP1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to PBXIP1/PBXIP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-IP1327-Ab-1/ GM-Tg-hg-IP1327-Ab-2Anti-Human PBXIP1 monoclonal antibodyHuman
GM-Tg-rg-IP1327-Ab-1/ GM-Tg-rg-IP1327-Ab-2Anti-Rat PBXIP1 monoclonal antibodyRat
GM-Tg-mg-IP1327-Ab-1/ GM-Tg-mg-IP1327-Ab-2Anti-Mouse PBXIP1 monoclonal antibodyMouse
GM-Tg-cynog-IP1327-Ab-1/ GM-Tg-cynog-IP1327-Ab-2Anti-Cynomolgus/ Rhesus macaque PBXIP1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-IP1327-Ab-1/ GM-Tg-felg-IP1327-Ab-2Anti-Feline PBXIP1 monoclonal antibodyFeline
GM-Tg-cang-IP1327-Ab-1/ GM-Tg-cang-IP1327-Ab-2Anti-Canine PBXIP1 monoclonal antibodyCanine
GM-Tg-bovg-IP1327-Ab-1/ GM-Tg-bovg-IP1327-Ab-2Anti-Bovine PBXIP1 monoclonal antibodyBovine
GM-Tg-equg-IP1327-Ab-1/ GM-Tg-equg-IP1327-Ab-2Anti-Equine PBXIP1 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-IP1327-Ab-1/ GM-Tg-hg-IP1327-Ab-2; GM-Tg-rg-IP1327-Ab-1/ GM-Tg-rg-IP1327-Ab-2;
GM-Tg-mg-IP1327-Ab-1/ GM-Tg-mg-IP1327-Ab-2; GM-Tg-cynog-IP1327-Ab-1/ GM-Tg-cynog-IP1327-Ab-2;
GM-Tg-felg-IP1327-Ab-1/ GM-Tg-felg-IP1327-Ab-2; GM-Tg-cang-IP1327-Ab-1/ GM-Tg-cang-IP1327-Ab-2;
GM-Tg-bovg-IP1327-Ab-1/ GM-Tg-bovg-IP1327-Ab-2; GM-Tg-equg-IP1327-Ab-1/ GM-Tg-equg-IP1327-Ab-2
Products NameAnti-PBXIP1 monoclonal antibody
Formatmab
Target NamePBXIP1
Protein Sub-locationIntrocelluar Protein
Category of antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-PBXIP1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-IP1327-Ag-1Recombinant multi-species PBIP1/ PBXIP1/ HPIP protein
    ORF Viral VectorpGMLP004353human PBXIP1 Lentivirus plasmid
    ORF Viral VectorvGMLP004353human PBXIP1 Lentivirus particle


    Target information

    Target IDGM-IP1327
    Target NamePBXIP1
    Gene ID57326,229534,310644,717036,480133,101096537,506485,100062988
    Gene Symbol and Synonyms4732463H20Rik,HPIP,PBXIP1
    Uniprot AccessionQ96AQ6,A2VD12,A6QLY7
    Uniprot Entry NamePBIP1_HUMAN,PBIP1_RAT,PBIP1_BOVIN
    Protein Sub-locationIntrocelluar Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000163346
    Target ClassificationN/A

    The target: PBXIP1, gene name: PBXIP1, also named as HPIP. The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined. [provided by RefSeq, Dec 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.