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Anti-GNPTAB monoclonal antibody
Pre-made anti-GNPTAB monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to GNPTAB/GNPTAB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0917-Ab-1/ GM-Tg-hg-IP0917-Ab-2 | Anti-Human GNPTAB monoclonal antibody | Human |
| GM-Tg-rg-IP0917-Ab-1/ GM-Tg-rg-IP0917-Ab-2 | Anti-Rat GNPTAB monoclonal antibody | Rat |
| GM-Tg-mg-IP0917-Ab-1/ GM-Tg-mg-IP0917-Ab-2 | Anti-Mouse GNPTAB monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0917-Ab-1/ GM-Tg-cynog-IP0917-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GNPTAB monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0917-Ab-1/ GM-Tg-felg-IP0917-Ab-2 | Anti-Feline GNPTAB monoclonal antibody | Feline |
| GM-Tg-cang-IP0917-Ab-1/ GM-Tg-cang-IP0917-Ab-2 | Anti-Canine GNPTAB monoclonal antibody | Canine |
| GM-Tg-bovg-IP0917-Ab-1/ GM-Tg-bovg-IP0917-Ab-2 | Anti-Bovine GNPTAB monoclonal antibody | Bovine |
| GM-Tg-equg-IP0917-Ab-1/ GM-Tg-equg-IP0917-Ab-2 | Anti-Equine GNPTAB monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0917-Ab-1/ GM-Tg-hg-IP0917-Ab-2; GM-Tg-rg-IP0917-Ab-1/ GM-Tg-rg-IP0917-Ab-2; GM-Tg-mg-IP0917-Ab-1/ GM-Tg-mg-IP0917-Ab-2; GM-Tg-cynog-IP0917-Ab-1/ GM-Tg-cynog-IP0917-Ab-2; GM-Tg-felg-IP0917-Ab-1/ GM-Tg-felg-IP0917-Ab-2; GM-Tg-cang-IP0917-Ab-1/ GM-Tg-cang-IP0917-Ab-2; GM-Tg-bovg-IP0917-Ab-1/ GM-Tg-bovg-IP0917-Ab-2; GM-Tg-equg-IP0917-Ab-1/ GM-Tg-equg-IP0917-Ab-2 |
| Products Name | Anti-GNPTAB monoclonal antibody |
| Format | mab |
| Target Name | GNPTAB |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-GNPTAB monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0917-Ag-1 | Recombinant multi-species GNPTA/ GNPTAB/ ICD protein |
Target information
| Target ID | GM-IP0917 |
| Target Name | GNPTAB |
| Gene ID | 79158,432486,362865,697307,475443,101100231,509610,100067011 |
| Gene Symbol and Synonyms | EG432486,GNPTA,GNPTAB,ICD,RGD1564821 |
| Uniprot Accession | Q3T906 |
| Uniprot Entry Name | GNPTA_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000111670 |
| Target Classification | N/A |
The target: GNPTAB, gene name: GNPTAB, also named as GNPTA, ICD. This gene encodes two of three subunit types of the membrane-bound enzyme N-acetylglucosamine-1-phosphotransferase, a heterohexameric complex composed of two alpha, two beta, and two gamma subunits. The encoded protein is proteolytically cleaved at the Lys928-Asp929 bond to yield mature alpha and beta polypeptides while the gamma subunits are the product of a distinct gene (GeneID 84572). In the Golgi apparatus, the heterohexameric complex catalyzes the first step in the synthesis of mannose 6-phosphate recognition markers on certain oligosaccharides of newly synthesized lysosomal enzymes. These recognition markers are essential for appropriate trafficking of lysosomal enzymes. Mutations in this gene have been associated with both mucolipidosis II and mucolipidosis IIIA.[provided by RefSeq, May 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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