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Anti-DERL3 monoclonal antibody
Pre-made anti-DERL3 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to DERL3/DERL3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0685-Ab-1/ GM-Tg-hg-IP0685-Ab-2 | Anti-Human DERL3 monoclonal antibody | Human |
| GM-Tg-rg-IP0685-Ab-1/ GM-Tg-rg-IP0685-Ab-2 | Anti-Rat DERL3 monoclonal antibody | Rat |
| GM-Tg-mg-IP0685-Ab-1/ GM-Tg-mg-IP0685-Ab-2 | Anti-Mouse DERL3 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0685-Ab-1/ GM-Tg-cynog-IP0685-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DERL3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0685-Ab-1/ GM-Tg-felg-IP0685-Ab-2 | Anti-Feline DERL3 monoclonal antibody | Feline |
| GM-Tg-cang-IP0685-Ab-1/ GM-Tg-cang-IP0685-Ab-2 | Anti-Canine DERL3 monoclonal antibody | Canine |
| GM-Tg-bovg-IP0685-Ab-1/ GM-Tg-bovg-IP0685-Ab-2 | Anti-Bovine DERL3 monoclonal antibody | Bovine |
| GM-Tg-equg-IP0685-Ab-1/ GM-Tg-equg-IP0685-Ab-2 | Anti-Equine DERL3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0685-Ab-1/ GM-Tg-hg-IP0685-Ab-2; GM-Tg-rg-IP0685-Ab-1/ GM-Tg-rg-IP0685-Ab-2; GM-Tg-mg-IP0685-Ab-1/ GM-Tg-mg-IP0685-Ab-2; GM-Tg-cynog-IP0685-Ab-1/ GM-Tg-cynog-IP0685-Ab-2; GM-Tg-felg-IP0685-Ab-1/ GM-Tg-felg-IP0685-Ab-2; GM-Tg-cang-IP0685-Ab-1/ GM-Tg-cang-IP0685-Ab-2; GM-Tg-bovg-IP0685-Ab-1/ GM-Tg-bovg-IP0685-Ab-2; GM-Tg-equg-IP0685-Ab-1/ GM-Tg-equg-IP0685-Ab-2 |
| Products Name | Anti-DERL3 monoclonal antibody |
| Format | mab |
| Target Name | DERL3 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-DERL3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0685-Ag-1 | Recombinant multi-species DERL3/ C22orf14/ IZP6 protein |
Target information
| Target ID | GM-IP0685 |
| Target Name | DERL3 |
| Gene ID | 91319,70377,690315,699316,486406,101089806,614334 |
| Gene Symbol and Synonyms | 1810006I20Rik,1810063P04Rik,C22orf14,DERL3,derlin-3,IZP6,LLN2 |
| Uniprot Accession | Q96Q80,Q0P5E4 |
| Uniprot Entry Name | DERL3_HUMAN,DERL3_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000099958 |
| Target Classification | N/A |
The target: DERL3, gene name: DERL3, also named as C22orf14, IZP6, LLN2, derlin-3. The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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