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Anti-DIABLO monoclonal antibody
Pre-made anti-DIABLO monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to DIABLO/DIABLO products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0216-Ab-1/ GM-Tg-hg-IP0216-Ab-2 | Anti-Human DIABLO monoclonal antibody | Human |
| GM-Tg-rg-IP0216-Ab-1/ GM-Tg-rg-IP0216-Ab-2 | Anti-Rat DIABLO monoclonal antibody | Rat |
| GM-Tg-mg-IP0216-Ab-1/ GM-Tg-mg-IP0216-Ab-2 | Anti-Mouse DIABLO monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0216-Ab-1/ GM-Tg-cynog-IP0216-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DIABLO monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0216-Ab-1/ GM-Tg-felg-IP0216-Ab-2 | Anti-Feline DIABLO monoclonal antibody | Feline |
| GM-Tg-cang-IP0216-Ab-1/ GM-Tg-cang-IP0216-Ab-2 | Anti-Canine DIABLO monoclonal antibody | Canine |
| GM-Tg-bovg-IP0216-Ab-1/ GM-Tg-bovg-IP0216-Ab-2 | Anti-Bovine DIABLO monoclonal antibody | Bovine |
| GM-Tg-equg-IP0216-Ab-1/ GM-Tg-equg-IP0216-Ab-2 | Anti-Equine DIABLO monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0216-Ab-1/ GM-Tg-hg-IP0216-Ab-2; GM-Tg-rg-IP0216-Ab-1/ GM-Tg-rg-IP0216-Ab-2; GM-Tg-mg-IP0216-Ab-1/ GM-Tg-mg-IP0216-Ab-2; GM-Tg-cynog-IP0216-Ab-1/ GM-Tg-cynog-IP0216-Ab-2; GM-Tg-felg-IP0216-Ab-1/ GM-Tg-felg-IP0216-Ab-2; GM-Tg-cang-IP0216-Ab-1/ GM-Tg-cang-IP0216-Ab-2; GM-Tg-bovg-IP0216-Ab-1/ GM-Tg-bovg-IP0216-Ab-2; GM-Tg-equg-IP0216-Ab-1/ GM-Tg-equg-IP0216-Ab-2 |
| Products Name | Anti-DIABLO monoclonal antibody |
| Format | mab |
| Target Name | DIABLO |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-DIABLO monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0216-Ag-1 | Recombinant multi-species DBLOH/ DIABLO/ DFNA64 protein |
| ORF Viral Vector | vGMLV000088 | human DIABLO Lentivirus particle |
| ORF Viral Vector | pGMLV000088 | human DIABLO Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000817 | mouse Diablo Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000817 | mouse Diablo Lentivirus particle |
Target information
| Target ID | GM-IP0216 |
| Target Name | DIABLO |
| Gene ID | 56616,66593,288753,701896,477463,768282,493999,100058709 |
| Gene Symbol and Synonyms | 0610041G12Rik,1700006L01Rik,DBO,DFNA64,DIABLO,SMAC |
| Uniprot Accession | Q9NR28 |
| Uniprot Entry Name | DBLOH_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000184047 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: DIABLO, gene name: DIABLO, also named as DFNA64, SMAC. This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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