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Anti-MAGEA4 monoclonal antibody
Pre-made anti-MAGEA4 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to MAGEA4/MAGEA4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0077-Ab-1/ GM-Tg-hg-IP0077-Ab-2 | Anti-Human MAGEA4 monoclonal antibody | Human |
| GM-Tg-rg-IP0077-Ab-1/ GM-Tg-rg-IP0077-Ab-2 | Anti-Rat MAGEA4 monoclonal antibody | Rat |
| GM-Tg-mg-IP0077-Ab-1/ GM-Tg-mg-IP0077-Ab-2 | Anti-Mouse MAGEA4 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0077-Ab-1/ GM-Tg-cynog-IP0077-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MAGEA4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0077-Ab-1/ GM-Tg-felg-IP0077-Ab-2 | Anti-Feline MAGEA4 monoclonal antibody | Feline |
| GM-Tg-cang-IP0077-Ab-1/ GM-Tg-cang-IP0077-Ab-2 | Anti-Canine MAGEA4 monoclonal antibody | Canine |
| GM-Tg-bovg-IP0077-Ab-1/ GM-Tg-bovg-IP0077-Ab-2 | Anti-Bovine MAGEA4 monoclonal antibody | Bovine |
| GM-Tg-equg-IP0077-Ab-1/ GM-Tg-equg-IP0077-Ab-2 | Anti-Equine MAGEA4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0077-Ab-1/ GM-Tg-hg-IP0077-Ab-2; GM-Tg-rg-IP0077-Ab-1/ GM-Tg-rg-IP0077-Ab-2; GM-Tg-mg-IP0077-Ab-1/ GM-Tg-mg-IP0077-Ab-2; GM-Tg-cynog-IP0077-Ab-1/ GM-Tg-cynog-IP0077-Ab-2; GM-Tg-felg-IP0077-Ab-1/ GM-Tg-felg-IP0077-Ab-2; GM-Tg-cang-IP0077-Ab-1/ GM-Tg-cang-IP0077-Ab-2; GM-Tg-bovg-IP0077-Ab-1/ GM-Tg-bovg-IP0077-Ab-2; GM-Tg-equg-IP0077-Ab-1/ GM-Tg-equg-IP0077-Ab-2 |
| Products Name | Anti-MAGEA4 monoclonal antibody |
| Format | mab |
| Target Name | MAGEA4 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-MAGEA4 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0077-Ag-1 | Recombinant multi-species MAGA4/ MAGEA4/ CT1.4 protein |
| ORF Viral Vector | pGMLP004051 | human MAGEA4 Lentivirus plasmid |
| ORF Viral Vector | vGMLP004051 | human MAGEA4 Lentivirus particle |
| ORF Viral Vector | pGMLPm003723 | mouse Magea4 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003723 | mouse Magea4 Lentivirus particle |
Target information
| Target ID | GM-IP0077 |
| Target Name | MAGEA4 |
| Gene ID | 4103,17140,710825 |
| Gene Symbol and Synonyms | CT1.4,MAGE-41,Mage-a4,MAGE-X2,MAGE4,MAGE4A,MAGE4B,MAGEA4 |
| Uniprot Accession | P43358 |
| Uniprot Entry Name | MAGA4_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index |
| Disease | Cancer |
| Gene Ensembl | ENSG00000147381 |
| Target Classification | Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA) |
The target: MAGEA4, gene name: MAGEA4, also named as CT1.4, MAGE-41, MAGE-X2, MAGE4, MAGE4A, MAGE4B. This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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