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Anti-OPRS1 monoclonal antibody
Pre-made anti-OPRS1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to OPRS1/SIGMAR1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0013-Ab-1/ GM-Tg-hg-IP0013-Ab-2 | Anti-Human OPRS1/SIGMAR1 monoclonal antibody | Human |
| GM-Tg-rg-IP0013-Ab-1/ GM-Tg-rg-IP0013-Ab-2 | Anti-Rat OPRS1/SIGMAR1 monoclonal antibody | Rat |
| GM-Tg-mg-IP0013-Ab-1/ GM-Tg-mg-IP0013-Ab-2 | Anti-Mouse OPRS1/SIGMAR1 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0013-Ab-1/ GM-Tg-cynog-IP0013-Ab-2 | Anti-Cynomolgus/ Rhesus macaque OPRS1/SIGMAR1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0013-Ab-1/ GM-Tg-felg-IP0013-Ab-2 | Anti-Feline OPRS1/SIGMAR1 monoclonal antibody | Feline |
| GM-Tg-cang-IP0013-Ab-1/ GM-Tg-cang-IP0013-Ab-2 | Anti-Canine OPRS1/SIGMAR1 monoclonal antibody | Canine |
| GM-Tg-bovg-IP0013-Ab-1/ GM-Tg-bovg-IP0013-Ab-2 | Anti-Bovine OPRS1/SIGMAR1 monoclonal antibody | Bovine |
| GM-Tg-equg-IP0013-Ab-1/ GM-Tg-equg-IP0013-Ab-2 | Anti-Equine OPRS1/SIGMAR1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0013-Ab-1/ GM-Tg-hg-IP0013-Ab-2; GM-Tg-rg-IP0013-Ab-1/ GM-Tg-rg-IP0013-Ab-2; GM-Tg-mg-IP0013-Ab-1/ GM-Tg-mg-IP0013-Ab-2; GM-Tg-cynog-IP0013-Ab-1/ GM-Tg-cynog-IP0013-Ab-2; GM-Tg-felg-IP0013-Ab-1/ GM-Tg-felg-IP0013-Ab-2; GM-Tg-cang-IP0013-Ab-1/ GM-Tg-cang-IP0013-Ab-2; GM-Tg-bovg-IP0013-Ab-1/ GM-Tg-bovg-IP0013-Ab-2; GM-Tg-equg-IP0013-Ab-1/ GM-Tg-equg-IP0013-Ab-2 |
| Products Name | Anti-OPRS1/SIGMAR1 monoclonal antibody |
| Format | mab |
| Target Name | OPRS1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-OPRS1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0013-Ag-1 | Recombinant multi-species SGMR1/ OPRS1/ SIGMAR1 protein |
| ORF Viral Vector | vGMLV000203 | human SIGMAR1 Lentivirus particle |
| ORF Viral Vector | pGMLV000203 | human SIGMAR1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm003847 | mouse Sigmar1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003847 | mouse Sigmar1 Lentivirus particle |
Target information
| Target ID | GM-IP0013 |
| Target Name | OPRS1 |
| Gene ID | 10280,18391,29336,700469,481587,101084912,538903,100068507 |
| Gene Symbol and Synonyms | ALS16,DSMA2,hSigmaR1,OPRS1,SIG-1R,Sig1R,sigma1R,SIGMAR1,SR-BP,SR-BP1,SRBP |
| Uniprot Accession | Q99720,Q9R0C9,Q58DH7 |
| Uniprot Entry Name | SGMR1_HUMAN,SGMR1_RAT,SGMR1_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000147955 |
| Target Classification | N/A |
The target: OPRS1, gene name: SIGMAR1, also named as ALS16, DSMA2, OPRS1, SIG-1R, SR-BP, SR-BP1, SRBP, hSigmaR1, sigma1R. This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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