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Anti-RORC monoclonal antibody
Pre-made anti-RORC monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to RORC/RORC products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IO129-Ab-1/ GM-Tg-hg-IO129-Ab-2 | Anti-Human RORC monoclonal antibody | Human |
| GM-Tg-rg-IO129-Ab-1/ GM-Tg-rg-IO129-Ab-2 | Anti-Rat RORC monoclonal antibody | Rat |
| GM-Tg-mg-IO129-Ab-1/ GM-Tg-mg-IO129-Ab-2 | Anti-Mouse RORC monoclonal antibody | Mouse |
| GM-Tg-cynog-IO129-Ab-1/ GM-Tg-cynog-IO129-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RORC monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IO129-Ab-1/ GM-Tg-felg-IO129-Ab-2 | Anti-Feline RORC monoclonal antibody | Feline |
| GM-Tg-cang-IO129-Ab-1/ GM-Tg-cang-IO129-Ab-2 | Anti-Canine RORC monoclonal antibody | Canine |
| GM-Tg-bovg-IO129-Ab-1/ GM-Tg-bovg-IO129-Ab-2 | Anti-Bovine RORC monoclonal antibody | Bovine |
| GM-Tg-equg-IO129-Ab-1/ GM-Tg-equg-IO129-Ab-2 | Anti-Equine RORC monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IO129-Ab-1/ GM-Tg-hg-IO129-Ab-2; GM-Tg-rg-IO129-Ab-1/ GM-Tg-rg-IO129-Ab-2; GM-Tg-mg-IO129-Ab-1/ GM-Tg-mg-IO129-Ab-2; GM-Tg-cynog-IO129-Ab-1/ GM-Tg-cynog-IO129-Ab-2; GM-Tg-felg-IO129-Ab-1/ GM-Tg-felg-IO129-Ab-2; GM-Tg-cang-IO129-Ab-1/ GM-Tg-cang-IO129-Ab-2; GM-Tg-bovg-IO129-Ab-1/ GM-Tg-bovg-IO129-Ab-2; GM-Tg-equg-IO129-Ab-1/ GM-Tg-equg-IO129-Ab-2 |
| Products Name | Anti-RORC monoclonal antibody |
| Format | mab |
| Target Name | RORC |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-RORC monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IO129-Ag-1 | Recombinant multi-species RORG/ RORC/ IMD42 protein |
| ORF Viral Vector | pGMLP004366 | human RORC Lentivirus plasmid |
| ORF Viral Vector | vGMLP004366 | human RORC Lentivirus particle |
| ORF Viral Vector | pGMLPm004387 | mouse Rorc Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004387 | mouse Rorc Lentivirus particle |
Target information
| Target ID | GM-IO129 |
| Target Name | RORC |
| Gene ID | 6097,19885,368158,717052,483205,101082078,527470,100060134 |
| Gene Symbol and Synonyms | IMD42,NR1F3,RORC,RORG,RORgamma,RZR-GAMMA,RZRG,Thor,TOR |
| Uniprot Accession | P51449 |
| Uniprot Entry Name | RORG_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target, Immuno-oncology Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000143365 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: RORC, gene name: RORC, also named as IMD42, NR1F3, RORG, RZR-GAMMA, RZRG, TOR. The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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