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Anti-IL17B/ IL-17B/ IL-20 functional antibody
Anti-IL17B/ IL-17B/ IL-20 functional antibody for cell culture, ELISA & in-vivo assay
Go to IL17B/IL17B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IO076-Ab-1/ GM-Tg-hg-IO076-Ab-2 | Anti-Human IL17B monoclonal antibody | Human |
| GM-Tg-rg-IO076-Ab-1/ GM-Tg-rg-IO076-Ab-2 | Anti-Rat IL17B monoclonal antibody | Rat |
| GM-Tg-mg-IO076-Ab-1/ GM-Tg-mg-IO076-Ab-2 | Anti-Mouse IL17B monoclonal antibody | Mouse |
| GM-Tg-cynog-IO076-Ab-1/ GM-Tg-cynog-IO076-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL17B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IO076-Ab-1/ GM-Tg-felg-IO076-Ab-2 | Anti-Feline IL17B monoclonal antibody | Feline |
| GM-Tg-cang-IO076-Ab-1/ GM-Tg-cang-IO076-Ab-2 | Anti-Canine IL17B monoclonal antibody | Canine |
| GM-Tg-bovg-IO076-Ab-1/ GM-Tg-bovg-IO076-Ab-2 | Anti-Bovine IL17B monoclonal antibody | Bovine |
| GM-Tg-equg-IO076-Ab-1/ GM-Tg-equg-IO076-Ab-2 | Anti-Equine IL17B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IO076-Ab-1/ GM-Tg-hg-IO076-Ab-2; GM-Tg-rg-IO076-Ab-1/ GM-Tg-rg-IO076-Ab-2; GM-Tg-mg-IO076-Ab-1/ GM-Tg-mg-IO076-Ab-2; GM-Tg-cynog-IO076-Ab-1/ GM-Tg-cynog-IO076-Ab-2; GM-Tg-felg-IO076-Ab-1/ GM-Tg-felg-IO076-Ab-2; GM-Tg-cang-IO076-Ab-1/ GM-Tg-cang-IO076-Ab-2; GM-Tg-bovg-IO076-Ab-1/ GM-Tg-bovg-IO076-Ab-2; GM-Tg-equg-IO076-Ab-1/ GM-Tg-equg-IO076-Ab-2 |
| Products Name | Anti-IL17B monoclonal antibody |
| Format | mab |
| Target Name | IL17B |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL17B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IO076-Ag-1 | Recombinant multi-species IL17B/ IL-17B/ IL-20 protein |
| Cytokine | GM-Tg-g-IO076-Ag-1 | interleukin 17B (IL17B) protein |
Target information
| Target ID | GM-IO076 |
| Target Name | IL17B |
| Gene ID | 27190,56069,116472,710679,489193,101086204,504992,100060593 |
| Gene Symbol and Synonyms | 1110006O16Rik,1700006N07Rik,IL-17B,IL-20,IL17B,NIRF,ZCYTO7 |
| Uniprot Accession | Q9UHF5 |
| Uniprot Entry Name | IL17B_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Immuno-oncology Target, Cytokine Target |
| Disease | Lung Cancer |
| Gene Ensembl | ENSG00000127743 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: IL17B, gene name: IL17B, also named as IL-17B, IL-20, NIRF, ZCYTO7. The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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