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Anti-I12R1/ IL12RB1/ CD212 monoclonal antibody
Anti-I12R1/ IL12RB1/ CD212 antibody for FACS & in-vivo assay
Go to IL12RB1/IL12RB1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IO073-Ab-1/ GM-Tg-hg-IO073-Ab-2 | Anti-Human IL12RB1 monoclonal antibody | Human |
| GM-Tg-rg-IO073-Ab-1/ GM-Tg-rg-IO073-Ab-2 | Anti-Rat IL12RB1 monoclonal antibody | Rat |
| GM-Tg-mg-IO073-Ab-1/ GM-Tg-mg-IO073-Ab-2 | Anti-Mouse IL12RB1 monoclonal antibody | Mouse |
| GM-Tg-cynog-IO073-Ab-1/ GM-Tg-cynog-IO073-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL12RB1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IO073-Ab-1/ GM-Tg-felg-IO073-Ab-2 | Anti-Feline IL12RB1 monoclonal antibody | Feline |
| GM-Tg-cang-IO073-Ab-1/ GM-Tg-cang-IO073-Ab-2 | Anti-Canine IL12RB1 monoclonal antibody | Canine |
| GM-Tg-bovg-IO073-Ab-1/ GM-Tg-bovg-IO073-Ab-2 | Anti-Bovine IL12RB1 monoclonal antibody | Bovine |
| GM-Tg-equg-IO073-Ab-1/ GM-Tg-equg-IO073-Ab-2 | Anti-Equine IL12RB1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IO073-Ab-1/ GM-Tg-hg-IO073-Ab-2; GM-Tg-rg-IO073-Ab-1/ GM-Tg-rg-IO073-Ab-2; GM-Tg-mg-IO073-Ab-1/ GM-Tg-mg-IO073-Ab-2; GM-Tg-cynog-IO073-Ab-1/ GM-Tg-cynog-IO073-Ab-2; GM-Tg-felg-IO073-Ab-1/ GM-Tg-felg-IO073-Ab-2; GM-Tg-cang-IO073-Ab-1/ GM-Tg-cang-IO073-Ab-2; GM-Tg-bovg-IO073-Ab-1/ GM-Tg-bovg-IO073-Ab-2; GM-Tg-equg-IO073-Ab-1/ GM-Tg-equg-IO073-Ab-2 |
| Products Name | Anti-IL12RB1 monoclonal antibody |
| Format | mab |
| Target Name | IL12RB1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL12RB1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species I12R1/ IL12RB1/ CD212 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-IO073-Ag-1 | interleukin 12 receptor, beta 1 (IL12RB1) protein |
Target information
| Target ID | GM-IO073 |
| Target Name | IL12RB1 |
| Gene ID | 3594,16161,171333,574199,484828,101093085,524299,100146965 |
| Gene Symbol and Synonyms | CD212,IL-12R,IL-12R-beta-1,IL-12R-BETA1,IL-12R[b],IL12RB,IL12RB1,IMD30 |
| Uniprot Accession | P42701 |
| Uniprot Entry Name | I12R1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000096996 |
| Target Classification | Checkpoint-Immuno Oncology, Cytokine Receptor |
The target: IL12RB1, gene name: IL12RB1, also named as CD212, IL-12R-BETA1, IL12RB, IMD30. The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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