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Anti-I10R1/ IL10R/ IL10RA monoclonal antibody
Anti-I10R1/ IL10R/ IL10RA antibody for FACS & in-vivo assay
Go to IL10R/IL10RA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IO069-Ab-1/ GM-Tg-hg-IO069-Ab-2 | Anti-Human IL10R/IL10RA monoclonal antibody | Human |
| GM-Tg-rg-IO069-Ab-1/ GM-Tg-rg-IO069-Ab-2 | Anti-Rat IL10R/IL10RA monoclonal antibody | Rat |
| GM-Tg-mg-IO069-Ab-1/ GM-Tg-mg-IO069-Ab-2 | Anti-Mouse IL10R/IL10RA monoclonal antibody | Mouse |
| GM-Tg-cynog-IO069-Ab-1/ GM-Tg-cynog-IO069-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL10R/IL10RA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IO069-Ab-1/ GM-Tg-felg-IO069-Ab-2 | Anti-Feline IL10R/IL10RA monoclonal antibody | Feline |
| GM-Tg-cang-IO069-Ab-1/ GM-Tg-cang-IO069-Ab-2 | Anti-Canine IL10R/IL10RA monoclonal antibody | Canine |
| GM-Tg-bovg-IO069-Ab-1/ GM-Tg-bovg-IO069-Ab-2 | Anti-Bovine IL10R/IL10RA monoclonal antibody | Bovine |
| GM-Tg-equg-IO069-Ab-1/ GM-Tg-equg-IO069-Ab-2 | Anti-Equine IL10R/IL10RA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IO069-Ab-1/ GM-Tg-hg-IO069-Ab-2; GM-Tg-rg-IO069-Ab-1/ GM-Tg-rg-IO069-Ab-2; GM-Tg-mg-IO069-Ab-1/ GM-Tg-mg-IO069-Ab-2; GM-Tg-cynog-IO069-Ab-1/ GM-Tg-cynog-IO069-Ab-2; GM-Tg-felg-IO069-Ab-1/ GM-Tg-felg-IO069-Ab-2; GM-Tg-cang-IO069-Ab-1/ GM-Tg-cang-IO069-Ab-2; GM-Tg-bovg-IO069-Ab-1/ GM-Tg-bovg-IO069-Ab-2; GM-Tg-equg-IO069-Ab-1/ GM-Tg-equg-IO069-Ab-2 |
| Products Name | Anti-IL10R/IL10RA monoclonal antibody |
| Format | mab |
| Target Name | IL10R |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL10R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species I10R1/ IL10R/ IL10RA VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-IO069-Ag-1 | interleukin 10 receptor, alpha (IL10RA) protein |
| ORF Viral Vector | pGMLPm005217 | mouse Il10ra Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005217 | mouse Il10ra Lentivirus particle |
Target information
| Target ID | GM-IO069 |
| Target Name | IL10R |
| Gene ID | 3587,16154,117539,704383,610823,101087601,513478,100071172 |
| Gene Symbol and Synonyms | CD210,CD210a,CDw210,CDW210A,HIL-10R,IL-10R1,IL-10RA,IL10R,IL10RA,mIL-10R |
| Uniprot Accession | Q13651 |
| Uniprot Entry Name | I10R1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000110324 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: IL10R, gene name: IL10RA, also named as CD210, CD210a, CDW210A, HIL-10R, IL-10R1, IL10R. The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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