Anti-INGR1/ IFNGR/ IFNGR1 monoclonal antibody

Anti-INGR1/ IFNGR/ IFNGR1 antibody for FACS & in-vivo assay

Target products collectionGo to IFNGR/IFNGR1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-IO066-Ab-1/ GM-Tg-hg-IO066-Ab-2Anti-Human IFNGR/IFNGR1 monoclonal antibodyHuman
GM-Tg-rg-IO066-Ab-1/ GM-Tg-rg-IO066-Ab-2Anti-Rat IFNGR/IFNGR1 monoclonal antibodyRat
GM-Tg-mg-IO066-Ab-1/ GM-Tg-mg-IO066-Ab-2Anti-Mouse IFNGR/IFNGR1 monoclonal antibodyMouse
GM-Tg-cynog-IO066-Ab-1/ GM-Tg-cynog-IO066-Ab-2Anti-Cynomolgus/ Rhesus macaque IFNGR/IFNGR1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-IO066-Ab-1/ GM-Tg-felg-IO066-Ab-2Anti-Feline IFNGR/IFNGR1 monoclonal antibodyFeline
GM-Tg-cang-IO066-Ab-1/ GM-Tg-cang-IO066-Ab-2Anti-Canine IFNGR/IFNGR1 monoclonal antibodyCanine
GM-Tg-bovg-IO066-Ab-1/ GM-Tg-bovg-IO066-Ab-2Anti-Bovine IFNGR/IFNGR1 monoclonal antibodyBovine
GM-Tg-equg-IO066-Ab-1/ GM-Tg-equg-IO066-Ab-2Anti-Equine IFNGR/IFNGR1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-IO066-Ab-1/ GM-Tg-hg-IO066-Ab-2; GM-Tg-rg-IO066-Ab-1/ GM-Tg-rg-IO066-Ab-2;
GM-Tg-mg-IO066-Ab-1/ GM-Tg-mg-IO066-Ab-2; GM-Tg-cynog-IO066-Ab-1/ GM-Tg-cynog-IO066-Ab-2;
GM-Tg-felg-IO066-Ab-1/ GM-Tg-felg-IO066-Ab-2; GM-Tg-cang-IO066-Ab-1/ GM-Tg-cang-IO066-Ab-2;
GM-Tg-bovg-IO066-Ab-1/ GM-Tg-bovg-IO066-Ab-2; GM-Tg-equg-IO066-Ab-1/ GM-Tg-equg-IO066-Ab-2
Products NameAnti-IFNGR/IFNGR1 monoclonal antibody
Formatmab
Target NameIFNGR
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IFNGR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-INN-874Pre-Made Interferon Gamma Biosimilar, Recombinant Protein targeting IFNGR1: Recombinant therapeutic protein targeting CD119/IFNGR/IMD27A/IMD27B
    Target AntigenProducts DevelopingMulti-species INGR1/ IFNGR/ IFNGR1 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLPm001350mouse Ifngr1 Lentivirus plasmid
    ORF Viral VectorvGMLPm001350mouse Ifngr1 Lentivirus particle


    Target information

    Target IDGM-IO066
    Target NameIFNGR
    Gene ID3459,15979,116465,100423877,100856077,101086811,508619,100073195
    Gene Symbol and SynonymsCD119,Ifgr,IFN-gammaR,IFNGR,IFNGR1,IFNR1,IMD27A,IMD27B,Nktar
    Uniprot AccessionP15260
    Uniprot Entry NameINGR1_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index
    DiseaseN/A
    Gene EnsemblENSG00000027697
    Target ClassificationCheckpoint-Immuno Oncology

    The target: IFNGR, gene name: IFNGR1, also named as CD119, IFNGR, IMD27A, IMD27B. This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.