Human GDNF/ATF/ATF1 ORF/cDNA clone-Lentivirus particle (NM_001190468)

Cat. No.: vGMLV001834

Pre-made Human GDNF/ATF/ATF1 Lentiviral expression plasmid for GDNF lentivirus packaging, GDNF lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

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Product information

Catalog No. Product Name lentivirus Grade lentivirus quantity
vGMLV001834 Human GDNF Lentivirus particle Pilot Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
Research Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
GMP-like Grade inquiry
GMP Grade inquiry


Product Description

Catalog ID vGMLV001834
Gene Name GDNF
Accession Number NM_001190468
Gene ID 2668
Species Human
Product Type Lentivirus particle (overexpression)
Insert Length 687 bp
Gene Alias ATF,ATF1,ATF2,HFB1-GDNF,HSCR3
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGCAGTCTTTGCCTAACAGCAATGGTGCCGCCGCCGGACGGGACTTTAAGATGAAGTTATGGGATGTCGTGGCTGTCTGCCTGGTGCTGCTCCACACCGCGTCCGCCTTCCCGCTGCCCGCCGGTAAGAGGCCTCCCGAGGCGCCCGCCGAAGACCGCTCCCTCGGCCGCCGCCGCGCGCCCTTCGCGCTGAGCAGTGACTCAAATATGCCAGAGGATTATCCTGATCAGTTCGATGATGTCATGGATTTTATTCAAGCCACCATTAAAAGACTGAAAAGGTCACCAGATAAACAAATGGCAGTGCTTCCTAGAAGAGAGCGGAATCGGCAGGCTGCAGCTGCCAACCCAGAGAATTCCAGAGGAAAAGGTCGGAGAGGCCAGAGGGGCAAAAACCGGGGTTGTGTCTTAACTGCAATACATTTAAATGTCACTGACTTGGGTCTGGGCTATGAAACCAAGGAGGAACTGATTTTTAGGTACTGCAGCGGCTCTTGCGATGCAGCTGAGACAACGTACGACAAAATATTGAAAAACTTATCCAGAAATAGAAGGCTGGTGAGTGACAAAGTAGGGCAGGCATGTTGCAGACCCATCGCCTTTGATGATGACCTGTCGTTTTTAGATGATAACCTGGTTTACCATATTCTAAGAAAGCATTCCGCTAAAAGGTGTGGATGTATCTGA
ORF Protein Sequence MQSLPNSNGAAAGRDFKMKLWDVVAVCLVLLHTASAFPLPAGKRPPEAPAEDRSLGRRRAPFALSSDSNMPEDYPDQFDDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T79160-Ab Anti-GDNF/ ATF/ ATF1 functional antibody
    Target Antigen GM-Tg-g-T79160-Ag GDNF protein
    Cytokine cks-Tg-g-GM-T79160 glial cell derived neurotrophic factor (GDNF) protein & antibody
    ORF Viral Vector pGMLP002678 Human GDNF Lentivirus plasmid
    ORF Viral Vector pGMLV000366 Human GDNF Lentivirus plasmid
    ORF Viral Vector pGMLV000484 Human GDNF Lentivirus plasmid
    ORF Viral Vector pGMLV001834 Human GDNF Lentivirus plasmid
    ORF Viral Vector pGMAP-SPh-284 Human GDNF Adenovirus plasmid
    ORF Viral Vector vGMLP002678 Human GDNF Lentivirus particle
    ORF Viral Vector vGMLV000366 Human GDNF Lentivirus particle
    ORF Viral Vector vGMLV000484 Human GDNF Lentivirus particle
    ORF Viral Vector vGMLV001834 Human GDNF Lentivirus particle
    ORF Viral Vector vGMAP-SPh-284 Human GDNF Adenovirus particle


    Target information

    Target ID GM-T79160
    Target Name GDNF
    Gene ID 2668, 14573, 706345, 25453, 101097871, 119871563, 386587, 100067053
    Gene Symbol and Synonyms ATF,ATF1,ATF2,GDNF,gndf,HFB1-GDNF,HSCR3
    Uniprot Accession P39905
    Uniprot Entry Name GDNF_HUMAN
    Protein Sub-location Secreted Protein/Potential Cytokines
    Category Therapeutics Target, Immuno-oncology Target, Cytokine Target
    Disease Lung Cancer
    Gene Ensembl ENSG00000168621
    Target Classification Checkpoint-Immuno Oncology

    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]



    About GMVC

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