Human CXCL8/GCP-1/GCP1 ORF/cDNA clone-Lentivirus particle (NM_000584.3)

Cat. No.: vGMLV000447

Pre-made Human CXCL8/GCP-1/GCP1 Lentiviral expression plasmid for CXCL8 lentivirus packaging, CXCL8 lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdf MSDS
pdf Datasheet

Product information

Catalog No. Product Name lentivirus Grade lentivirus quantity
vGMLV000447 Human CXCL8 Lentivirus particle Pilot Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
Research Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
GMP-like Grade inquiry
GMP Grade inquiry


Product Description

Catalog ID vGMLV000447
Gene Name CXCL8
Accession Number NM_000584.3
Gene ID 3576
Species Human
Product Type Lentivirus particle (overexpression)
Insert Length 300 bp
Gene Alias GCP-1,GCP1,IL8,LECT,LUCT,LYNAP,MDNCF,MONAP,NAF,NAP-1,NAP1
Fluorescent Reporter mcherry-Firefly luciferase
Mammalian Cell Selection Null
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
Sequence 正确

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T22658-Ab Anti-IL8/ CXCL8/ GCP-1 functional antibody
    Target Antigen GM-Tg-g-T22658-Ag IL8/CXCL8 protein
    Cytokine cks-Tg-g-GM-T22658 interleukin 8 (IL8) protein & antibody
    ORF Viral Vector pGMLV000447 Human CXCL8 Lentivirus plasmid
    ORF Viral Vector pGMLV000943 Human CXCL8 Lentivirus plasmid
    ORF Viral Vector pGMLV001490 Human CXCL8 Lentivirus plasmid
    ORF Viral Vector pGMAD000710 Human CXCL8 Adenovirus plasmid
    ORF Viral Vector pGMAP000556 Human IL8 Adenovirus plasmid
    ORF Viral Vector pGMLP-IL-011 Human CXCL8 Lentivirus plasmid
    ORF Viral Vector pGMAP-IL-094 Human CXCL8 Adenovirus plasmid
    ORF Viral Vector vGMLV000447 Human CXCL8 Lentivirus particle
    ORF Viral Vector vGMLV000943 Human CXCL8 Lentivirus particle
    ORF Viral Vector vGMLV001490 Human CXCL8 Lentivirus particle
    ORF Viral Vector vGMAD000710 Human CXCL8 Adenovirus particle
    ORF Viral Vector vGMAP000556 Human IL8 Adenovirus particle
    ORF Viral Vector vGMLP-IL-011 Human CXCL8 Lentivirus particle
    ORF Viral Vector vGMAP-IL-094 Human CXCL8 Adenovirus particle


    Target information

    Target ID GM-T22658
    Target Name IL8
    Gene ID 3576, 613028, 403850, 280828, 100037400
    Gene Symbol and Synonyms CXCL8,GCP-1,GCP1,IL-8,IL8,LECT,LUCT,LYNAP,MDNCF,MONAP,NAF,NAP-1,NAP1,SCYB8
    Uniprot Accession P10145
    Uniprot Entry Name IL8_HUMAN
    Protein Sub-location Secreted Protein/Potential Cytokines
    Category Therapeutics Target, Immuno-oncology Target, Cytokine Target
    Disease Not Available
    Gene Ensembl ENSG00000169429
    Target Classification Checkpoint-Immuno Oncology

    The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is commonly referred to as interleukin-8 (IL-8). IL-8 is secreted by mononuclear macrophages, neutrophils, eosinophils, T lymphocytes, epithelial cells, and fibroblasts. It functions as a chemotactic factor by guiding the neutrophils to the site of infection. Bacterial and viral products rapidly induce IL-8 expression. IL-8 also participates with other cytokines in the proinflammatory signaling cascade and plays a role in systemic inflammatory response syndrome (SIRS). This gene is believed to play a role in the pathogenesis of the lower respiratory tract infection bronchiolitis, a common respiratory tract disease caused by the respiratory syncytial virus (RSV). The overproduction of this proinflammatory protein is thought to cause the lung inflammation associated with csytic fibrosis. This proinflammatory protein is also suspected of playing a role in coronary artery disease and endothelial dysfunction. This protein is also secreted by tumor cells and promotes tumor migration, invasion, angiogenesis and metastasis. This chemokine is also a potent angiogenic factor. The binding of IL-8 to one of its receptors (IL-8RB/CXCR2) increases the permeability of blood vessels and increasing levels of IL-8 are positively correlated with increased severity of multiple disease outcomes (eg, sepsis). This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, May 2020]



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