Human CDK6/MCPH12/PLSTIRE ORF/cDNA clone-Lentivirus particle (NM_001259.6)

Cat. No.: vGMLP005616

Pre-made Human CDK6/MCPH12/PLSTIRE Lentiviral expression plasmid for CDK6 lentivirus packaging, CDK6 lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

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Product information

Catalog No. Product Name lentivirus Grade lentivirus quantity
vGMLP005616 Human CDK6 Lentivirus particle Pilot Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
Research Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
GMP-like Grade inquiry
GMP Grade inquiry


Product Description

Catalog ID vGMLP005616
Gene Name CDK6
Accession Number NM_001259.6
Gene ID 1021
Species Human
Product Type Lentivirus particle (overexpression)
Insert Length 981 bp
Gene Alias MCPH12,PLSTIRE
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGGAGAAGGACGGCCTGTGCCGCGCTGACCAGCAGTACGAATGCGTGGCGGAGATCGGGGAGGGCGCCTATGGGAAGGTGTTCAAGGCCCGCGACTTGAAGAACGGAGGCCGTTTCGTGGCGTTGAAGCGCGTGCGGGTGCAGACCGGCGAGGAGGGCATGCCGCTCTCCACCATCCGCGAGGTGGCGGTGCTGAGGCACCTGGAGACCTTCGAGCACCCCAACGTGGTCAGGTTGTTTGATGTGTGCACAGTGTCACGAACAGACAGAGAAACCAAACTAACTTTAGTGTTTGAACATGTCGATCAAGACTTGACCACTTACTTGGATAAAGTTCCAGAGCCTGGAGTGCCCACTGAAACCATAAAGGATATGATGTTTCAGCTTCTCCGAGGTCTGGACTTTCTTCATTCACACCGAGTAGTGCATCGCGATCTAAAACCACAGAACATTCTGGTGACCAGCAGCGGACAAATAAAACTCGCTGACTTCGGCCTTGCCCGCATCTATAGTTTCCAGATGGCTCTAACCTCAGTGGTCGTCACGCTGTGGTACAGAGCACCCGAAGTCTTGCTCCAGTCCAGCTACGCCACCCCCGTGGATCTCTGGAGTGTTGGCTGCATATTTGCAGAAATGTTTCGTAGAAAGCCTCTTTTTCGTGGAAGTTCAGATGTTGATCAACTAGGAAAAATCTTGGACGTGATTGGACTCCCAGGAGAAGAAGACTGGCCTAGAGATGTTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGCCCAACCAATTGAGAAGTTTGTAACAGATATCGATGAACTAGGCAAAGACCTACTTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGAATATCTGCCTACAGTGCCCTGTCTCACCCATACTTCCAGGACCTGGAAAGGTGCAAAGAAAACCTGGATTCCCACCTGCCGCCCAGCCAGAACACCTCGGAGCTGAATACAGCCTGA
ORF Protein Sequence MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T89361-Ab Anti-CDK6 monoclonal antibody
    Target Antigen GM-Tg-g-T89361-Ag CDK6 protein
    ORF Viral Vector pGMLP000458 Human CDK6 Lentivirus plasmid
    ORF Viral Vector pGMLP005302 Human CDK6 Lentivirus plasmid
    ORF Viral Vector pGMLP005616 Human CDK6 Lentivirus plasmid
    ORF Viral Vector pGMAP000280 Human CDK6 Adenovirus plasmid
    ORF Viral Vector pGMPC000873 Human CDK6 Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLP000458 Human CDK6 Lentivirus particle
    ORF Viral Vector vGMLP005302 Human CDK6 Lentivirus particle
    ORF Viral Vector vGMLP005616 Human CDK6 Lentivirus particle
    ORF Viral Vector vGMAP000280 Human CDK6 Adenovirus particle


    Target information

    Target ID GM-T89361
    Target Name CDK6
    Gene ID 1021, 12571, 701822, 114483, 100037415, 609920, 511754, 100061625
    Gene Symbol and Synonyms CDK6,Crk2,MCPH12,PLSTIRE
    Uniprot Accession Q00534
    Uniprot Entry Name CDK6_HUMAN
    Protein Sub-location Introcelluar Protein
    Category Therapeutics Target
    Disease breast tumor
    Gene Ensembl ENSG00000105810
    Target Classification Kinase

    The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017]



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