Human VKORC1/EDTP308/MST134 ORF/cDNA clone-Lentivirus particle (NM_024006)

Cat. No.: vGMLP003324

Pre-made Human VKORC1/EDTP308/MST134 Lentiviral expression plasmid for VKORC1 lentivirus packaging, VKORC1 lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

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Product information

Catalog No. Product Name lentivirus Grade lentivirus quantity
vGMLP003324 Human VKORC1 Lentivirus particle Pilot Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
Research Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
GMP-like Grade inquiry
GMP Grade inquiry


Product Description

Catalog ID vGMLP003324
Gene Name VKORC1
Accession Number NM_024006
Gene ID 79001
Species Human
Product Type Lentivirus particle (overexpression)
Insert Length 492 bp
Gene Alias EDTP308,MST134,MST576,VKCFD2,VKOR
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGGGCAGCACCTGGGGGAGCCCTGGCTGGGTGCGGCTCGCTCTTTGCCTGACGGGCTTAGTGCTCTCGCTCTACGCGCTGCACGTGAAGGCGGCGCGCGCCCGGGACCGGGATTACCGCGCGCTCTGCGACGTGGGCACCGCCATCAGCTGTTCGCGCGTCTTCTCCTCCAGGTGGGGCAGGGGTTTCGGGCTGGTGGAGCATGTGCTGGGACAGGACAGCATCCTCAATCAATCCAACAGCATATTCGGTTGCATCTTCTACACACTACAGCTATTGTTAGGTTGCCTGCGGACACGCTGGGCCTCTGTCCTGATGCTGCTGAGCTCCCTGGTGTCTCTCGCTGGTTCTGTCTACCTGGCCTGGATCCTGTTCTTCGTGCTCTATGATTTCTGCATTGTTTGTATCACCACCTATGCTATCAACGTGAGCCTGATGTGGCTCAGTTTCCGGAAGGTCCAAGAACCCCAGGGCAAGGCTAAGAGGCACTGA
ORF Protein Sequence MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWGRGFGLVEHVLGQDSILNQSNSIFGCIFYTLQLLLGCLRTRWASVLMLLSSLVSLAGSVYLAWILFFVLYDFCIVCITTYAINVSLMWLSFRKVQEPQGKAKRH

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T11843-Ab Anti-VKOR1/ VKORC1/ EDTP308 functional antibody
    Target Antigen GM-Tg-g-T11843-Ag VKORC1 protein
    ORF Viral Vector pGMLP003324 Human VKORC1 Lentivirus plasmid
    ORF Viral Vector pGMPC001739 Human VKORC1 Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLP003324 Human VKORC1 Lentivirus particle


    Target information

    Target ID GM-T11843
    Target Name VKORC1
    Gene ID 79001, 27973, 714412, 309004, 101089669, 479775, 445422, 100063360
    Gene Symbol and Synonyms D7Wsu86e,EDTP308,MST134,MST576,VKCFD2,VKOR,VKORC1
    Uniprot Accession Q9BQB6
    Uniprot Entry Name VKOR1_HUMAN
    Protein Sub-location Secreted Protein/Potential Cytokines
    Category Therapeutics Target
    Disease Not Available
    Gene Ensembl ENSG00000167397
    Target Classification Not Available

    This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes. Allelic variation in this gene is associated with vitamin k-dependent clotting factors combined deficiency of 2, and increased resistance or sensitivity to warfarin, an inhibitor of vitamin K epoxide reductase. Pseudogenes of this gene are located on chromosomes 1 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]



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