Human HBA2/HBA-T2/HBH ORF/cDNA clone-Lentivirus particle (NM_000517)

Cat. No.: vGMLP000959

Pre-made Human HBA2/HBA-T2/HBH Lentiviral expression plasmid for HBA2 lentivirus packaging, HBA2 lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name lentivirus Grade lentivirus quantity
vGMLP000959 Human HBA2 Lentivirus particle Pilot Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
Research Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
GMP-like Grade inquiry
GMP Grade inquiry


Product Description

Catalog ID vGMLP000959
Gene Name HBA2
Accession Number NM_000517
Gene ID 3040
Species Human
Product Type Lentivirus particle (overexpression)
Insert Length 429 bp
Gene Alias HBA-T2,HBH
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGGTGCTGTCTCCTGCCGACAAGACCAACGTCAAGGCCGCCTGGGGTAAGGTCGGCGCGCACGCTGGCGAGTATGGTGCGGAGGCCCTGGAGAGGATGTTCCTGTCCTTCCCCACCACCAAGACCTACTTCCCGCACTTCGACCTGAGCCACGGCTCTGCCCAGGTTAAGGGCCACGGCAAGAAGGTGGCCGACGCGCTGACCAACGCCGTGGCGCACGTGGACGACATGCCCAACGCGCTGTCCGCCCTGAGCGACCTGCACGCGCACAAGCTTCGGGTGGACCCGGTCAACTTCAAGCTCCTAAGCCACTGCCTGCTGGTGACCCTGGCCGCCCACCTCCCCGCCGAGTTCACCCCTGCGGTGCACGCCTCCCTGGACAAGTTCCTGGCTTCTGTGAGCACCGTGCTGACCTCCAAATACCGTTAA
ORF Protein Sequence MVLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T49493-Ab Anti-HB monoclonal antibody
    Target Antigen GM-Tg-g-T49493-Ag HB/HBA2 protein
    ORF Viral Vector pGMLP000959 Human HBA2 Lentivirus plasmid
    ORF Viral Vector pGMLP002912 Human HBA1 Lentivirus plasmid
    ORF Viral Vector vGMLP000959 Human HBA2 Lentivirus particle
    ORF Viral Vector vGMLP002912 Human HBA1 Lentivirus particle


    Target information

    Target ID GM-T49493
    Target Name HB
    Gene ID 3040
    Gene Symbol and Synonyms ECYT7,HBA-T2,HBA2,HBH
    Uniprot Accession P69905
    Uniprot Entry Name HBA_HUMAN
    Protein Sub-location Introcelluar Protein
    Category Therapeutics Target
    Disease Alzheimer's Disease, congestive heart failure, Diabetes type-2
    Gene Ensembl ENSG00000188536
    Target Classification Not Available

    The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. [provided by RefSeq, Jul 2008]



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