Human RUNX1/AML1/AML1-EVI-1 ORF/cDNA clone-Mammalian (Non-Viral Vector) plasmid (NM_001001890.3)

Cat. No.: pGMPC001636
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human RUNX1/AML1/AML1-EVI-1 Non-Viral expression plasmid (overexpression vector) for mouse RUNX1 overexpression in unique cell transient transfection and stable cell line development.

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Product Description

Catalog ID pGMPC001636
Gene Name RUNX1
Accession Number NM_001001890.3
Gene ID 861
Species Human
Product Type Mammalian (Non-Viral Vector) plasmid (overexpression)
Insert Length 1362 bp
Gene Alias AML1,AML1-EVI-1,AMLCR1,CBF2alpha,CBFA2,EVI-1,PEBP2aB,PEBP2alpha
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin

Reference




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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T43711-Ab Anti-RUNX1 monoclonal antibody
    Target Antigen GM-Tg-g-T43711-Ag RUNX1 protein
    ORF Viral Vector pGMLV000314 Human RUNX1 Lentivirus plasmid
    ORF Viral Vector pGMLV000843 Human RUNX1 Lentivirus plasmid
    ORF Viral Vector pGMPC001443 Human RUNX1 Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector pGMPC001636 Human RUNX1 Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLV000314 Human RUNX1 Lentivirus particle
    ORF Viral Vector vGMLV000843 Human RUNX1 Lentivirus particle


    Target information

    Target ID GM-T43711
    Target Name RUNX1
    Gene ID 861, 12394, 696749, 50662, 101084898, 487746, 529631, 100051950
    Gene Symbol and Synonyms AML1,AML1-EVI-1,AMLCR1,CBF-alpha-2,CBF2alpha,CBFA2,EVI-1,PEA2-alpha,PEBP2-alpha,Pebp2a2,PEBP2aB,PEBP2alpha,Pebpa2b,RUNX1
    Uniprot Accession Q01196
    Uniprot Entry Name RUNX1_HUMAN
    Protein Sub-location Introcelluar Protein
    Category Therapeutics Target
    Disease Cancer
    Gene Ensembl ENSG00000159216
    Target Classification Tumor-associated antigen (TAA)

    Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]



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