Human CXCR2/CD182/CDw128b ORF/cDNA clone-Mammalian (Non-Viral Vector) plasmid (NM_001557.4)

Cat. No.: pGMPC000938
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human CXCR2/CD182/CDw128b Non-Viral expression plasmid (overexpression vector) for mouse CXCR2 overexpression in unique cell transient transfection and stable cell line development.

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Product Description

Catalog ID pGMPC000938
Gene Name CXCR2
Accession Number NM_001557.4
Gene ID 3579
Species Human
Product Type Mammalian (Non-Viral Vector) plasmid (overexpression)
Insert Length 1083 bp
Gene Alias CD182,CDw128b,CMKAR2,IL8R2,IL8RA,IL8RB,WHIMS2
Fluorescent Reporter EGFP
Mammalian Cell Selection Null
Fusion Tag 3xflag (C-Terminal)
Promoter EF1
Resistance Amplicin

Reference




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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T56923-Ab Anti-CXCR2/ CD182/ CDw128b monoclonal antibody
    Target Antigen GM-Tg-g-T56923-Ag CXCR2 VLP (virus-like particle)
    Cytokine cks-Tg-g-GM-T56923 chemokine (C-X-C motif) receptor 2 (CXCR2) protein & antibody
    ORF Viral Vector pGMLP001481 Human CXCR2 Lentivirus plasmid
    ORF Viral Vector pGMLV002388 Human CXCR2 Lentivirus plasmid
    ORF Viral Vector pGMPC000938 Human CXCR2 Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLP001481 Human CXCR2 Lentivirus particle
    ORF Viral Vector vGMLV002388 Human CXCR2 Lentivirus particle


    Target information

    Target ID GM-T56923
    Target Name CXCR2
    Gene ID 3579, 12765, 700407, 29385, 101085396, 478905, 782719, 100055552
    Gene Symbol and Synonyms CD128,CD182,CDw128,CDw128b,CMKAR2,CXC-R2,CXCR-2,CXCR2,Gpcr16,IL-8rb,IL-8Rh,IL8R2,IL8RA,IL8RB,mIL-8RH,WHIMS2
    Uniprot Accession P25025
    Uniprot Entry Name CXCR2_HUMAN
    Protein Sub-location Transmembrane Protein
    Category Therapeutics Target, Immuno-oncology Target, Cytokine Target
    Disease Cancer
    Gene Ensembl ENSG00000180871
    Target Classification Checkpoint-Immuno Oncology, GPCR, Tumor-associated antigen (TAA)

    The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]



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