Human ATF4/CREB-2/ CREB2 ORF/cDNA clone-Mammalian (Non-Viral Vector) plasmid (NM_001675)

Product information

Catalog No.	Product Name	Plasmid Grade	Plasmid quantity
pGMPC000693	Human ATF4 Mammalian (Non-Viral Vector) plasmid	Research Grade	10mg, 50mg, 100mg, 500mg, >1g
		GMP-like Grade	10mg, 50mg, 100mg, 500mg, >1g
		High Quality (HQ) Grade
		Seed	5ug

Product Description

Catalog ID	pGMPC000693
Gene Name	ATF4
Accession Number	NM_001675
Gene ID	468
Species	Human
Product Type	Mammalian (Non-Viral Vector) plasmid (overexpression)
Insert Length	1056 bp
Gene Alias	CREB-2, CREB2, TAXREB67, TXREB
Fluorescent Reporter
Mammalian Cell Selection	Null
Fusion Tag	Null
Promoter	CMV
Resistance	Amplicin
Sequence	ATGACCGAAATGAGCTTCCTGAGCAGCGAGGTGTTGGTGGGGGACTTGATGTCCCCCTTCGACCAGTCGGGTTTGGGGGCTGAAGAAAGCCTAGGTCTCTTAGATGATTACCTGGAGGTGGCCAAGCACTTCAAACCTCATGGGTTCTCCAGCGACAAGGCTAAGGCGGGCTCCTCCGAATGGCTGGCTGTGGATGGGTTGGTCAGTCCCTCCAACAACAGCAAGGAGGATGCCTTCTCCGGGACAGATTGGATGTTGGAGAAAATGGATTTGAAGGAGTTCGACTTGGATGCCCTGTTGGGTATAGATGACCTGGAAACCATGCCAGATGACCTTCTGACCACGTTGGATGACACTTGTGATCTCTTTGCCCCCCTAGTCCAGGAGACTAATAAGCAGCCCCCCCAGACGGTGAACCCAATTGGCCATCTCCCAGAAAGTTTAACAAAACCCGACCAGGTTGCCCCCTTCACCTTCTTACAACCTCTTCCCCTTTCCCCAGGGGTCCTGTCCTCCACTCCAGATCATTCCTTTAGTTTAGAGCTGGGCAGTGAAGTGGATATCACTGAAGGAGATAGGAAGCCAGACTACACTGCTTACGTTGCCATGATCCCTCAGTGCATAAAGGAGGAAGACACCCCTTCAGATAATGATAGTGGCATCTGTATGAGCCCAGAGTCCTATCTGGGGTCTCCTCAGCACAGCCCCTCTACCAGGGGCTCTCCAAATAGGAGCCTCCCATCTCCAGGTGTTCTCTGTGGGTCTGCCCGTCCCAAACCTTACGATCCTCCTGGAGAGAAGATGGTAGCAGCAAAAGTAAAGGGTGAGAAACTGGATAAGAAGCTGAAAAAAATGGAGCAAAACAAGACAGCAGCCACTAGGTACCGCCAGAAGAAGAGGGCGGAGCAGGAGGCTCTTACTGGTGAGTGCAAAGAGCTGGAAAAGAAGAACGAGGCTCTAAAAGAGAGGGCGGATTCCCTGGCCAAGGAGATCCAGTACCTGAAAGATTTGATAGAAGAGGTCCGCAAGGCAAGGGGGAAGAAAAGGGTCCCCTAG

Reference

Data / case study

Click to get more Data / Case study about the product.

Associated products

Category	Cat No.	Products Name
Target Antibody	GM-Tg-g-T53270-Ab	Anti-ATF-4 monoclonal antibody
Target Antigen	GM-Tg-g-T53270-Ag	ATF-4/ATF4 protein
ORF Viral Vector	pGMLV000321	Human ATF4 Lentivirus plasmid
ORF Viral Vector	pGMLV000496	Human ATF4 Lentivirus plasmid
ORF Viral Vector	pGMAAV000923	Rat Atf4 Adeno-associate virus(AAV) plasmid
ORF Viral Vector	pGMPC000693	Human ATF4 Mammalian (Non-Viral Vector) plasmid
ORF Viral Vector	vGMLV000321	Human ATF4 Lentivirus particle
ORF Viral Vector	vGMLV000496	Human ATF4 Lentivirus particle
ORF Viral Vector	vGMAAV000923	Rat Atf4 Adeno-associate virus(AAV) particle

Target information

Target ID	GM-T53270
Target Name	ATF-4
Gene ID	468, 11911, 703965, 79255, 101084297, 474503, 509107, 100070334
Gene Symbol and Synonyms	Atf-4,ATF4,C/ATF,CREB-2,CREB2,TAXREB67,TXREB
Uniprot Accession	P18848
Uniprot Entry Name	ATF4_HUMAN
Protein Sub-location	Introcelluar Protein
Category	Therapeutics Target
Disease	Cancer
Gene Ensembl	ENSG00000128272
Target Classification	Tumor-associated antigen (TAA)

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]

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